Engineering cohesion and adhesion through dynamic bonds for advanced adhesive materials

Wan, Yichen; Qiu, Wenlian; Zhu, He; Zhang, Qi; Zhu, Shiping

doi:10.1002/cjce.24849

Cited by 9 publications

(6 citation statements)

References 95 publications

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“…The resulting adhesion energies of the hydrogels H1, H2, and H3 in the presence of mucin are 0.249, 0.167, and 0.343 J/m 2 , respectively. If we recall the adhesion energies for the hydrogels without mucin, of 1.124, 1.273, and 9.144 J/m 2 , respectively, we can determine a so-called binding energy or cohesion energy [103][104][105] between hydrogels and mucin as a difference, i.e., 0.875, 1.106, and 8.801 J/m 2 for the three hydrogels, H1, H2, and H3, respectively. This indicates a very high cohesion energy in the ternary hydrogel.…”

Section: Rheological Studies Of Hydrogel-mucin Complexmentioning

confidence: 99%

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Moraru,

Dima,

Tritean

et al. 2023

Pharmaceuticals

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Biocompatible drug-delivery systems for soft tissue applications are of high interest for the medical and pharmaceutical fields. The subject of this research is the development of hydrogels loaded with bioactive compounds (inulin, thyme essential oil, hydro-glycero-alcoholic extract of Vitis vinifera, Opuntia ficus-indica powder, lactic acid, citric acid) in order to support the vaginal microbiota homeostasis. The nanofibrillar phyto-hydrogel systems developed using the biocompatible polymers chitosan (CS), never-dried bacterial nanocellulose (NDBNC), and Poloxamer 407 (PX) incorporated the water-soluble bioactive components in the NDBNC hydrophilic fraction and the hydrophobic components in the hydrophobic core of the PX fraction. Two NDBNC-PX hydrogels and one NDBNC-PX-CS hydrogel were structurally and physical-chemically characterized using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and rheology. The hydrogels were also evaluated in terms of thermo-responsive properties, mucoadhesion, biocompatibility, and prebiotic and antimicrobial effects. The mucin binding efficiency of hydrogel base systems was determined by the periodic acid/Schiff base (PAS) assay. Biocompatibility of hydrogel systems was determined by the MTT test using mouse fibroblasts. The prebiotic activity was determined using the probiotic strains Limosilactobacillus reuteri and Lactiplantibacillus plantarum subsp. plantarum. Antimicrobial activity was also assessed using relevant microbial strains, respectively, E. coli and C. albicans. TEM evidenced PX micelles of around 20 nm on NDBNC nanofibrils. The FTIR and XRD analyses revealed that the binary hydrogels are dominated by PX signals, and that the ternary hydrogel is dominated by CS, with additional particular fingerprints for the biocompounds and the hydrogel interaction with mucin. Rheology evidenced the gel transition temperatures of 18–22 °C for the binary hydrogels with thixotropic behavior and, respectively, no gel transition, with rheopectic behavior for the ternary hydrogel. The adhesion energies of the binary and ternary hydrogels were evaluated to be around 1.2 J/m2 and 9.1 J/m2, respectively. The hydrogels exhibited a high degree of biocompatibility, with the potential to support cell proliferation and also to promote the growth of lactobacilli. The hydrogel systems also presented significant antimicrobial and antibiofilm activity.

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Section: Rheological Studies Of Hydrogel-mucin Complexmentioning

confidence: 99%

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Moraru,

Dima,

Tritean

et al. 2023

Pharmaceuticals

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“…The authors of the articles in this issue join us from many countries and institutions across the globe (Figure 1 and Table 1) to thank Archie for his enduring legacy in polymerization reaction engineering, a field of academic and industrial interest that he established practically single‐handedly. [ 1–45 ]…”

Section: Figurementioning

confidence: 99%

Archie E. Hamielec memorial issue

et al. 2023

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“…[89,90] However, in fabrication of tissue-adhesive hydrogels, the covalent disulfide bonds are mainly means of inducing cohesion strength for hydrogels via S-S cross-links rather than chemical junctions at the hydrogel-tissue interface. [91]…”

Section: Covalent Bondsmentioning

confidence: 99%

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

Ho,

van Hilst,

Cui

et al. 2023

Advanced NanoBiomed Research

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The use of tissue adhesives dates to 1940s when surgical glues were introduced for wound closure applications. However, current clinically used tissue adhesives (fibrin and cyanoacrylate glues) have limited adhesion strength and biocompatibility issues which restrict their performance in targeted applications. Due to this unmet clinical challenge, there is a need to develop next‐generation tissue adhesives to expand the current limited available options. Another factor that is often overlooked in the field is the consequence of when these tissue adhesives fail while in use in specific applications. In this review, the complications arising from tissue adhesives that have insufficient adhesion strength are covered, where unintentional loosening and detachment can lead to serious complications depending on both the applications and scenarios in which the adhesives are used. Next, the current methodologies employed to design tissue‐adhesive hydrogels targeting specific applications are also collated. Finally, the different strategies to engineer on‐demand removal property of these tissue‐adhesive hydrogels are consolidated, including some perspectives on current challenges and outlooks in this field.

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Engineering cohesion and adhesion through dynamic bonds for advanced adhesive materials

Cited by 9 publications

References 95 publications

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Archie E. Hamielec memorial issue

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

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