Engineering carbonyl reductase for one-pot chemobiocatalytic enantioselective synthesis of a value-added N-containing chiral alcohol from N-acetyl-d-glucosamine

Abstract

Direct chemobiocatalytic conversion of biomass into value-added chemicals is promising yet challenging, because of the combined advantages of the two technologies and their incompatible issues. In this work, structure-guided engineering...

Defect Compensation and Lattice Stabilization Enables High Voltage Output in Tin Halide Perovskite Solar Cells

“…To date, many strategies have been reported to address the oxidation issues, such as the solvent engineering, [20,21] crystallization regulation, [6] vacuum-flash treatment, [22] hollow crystal structure, [23] 2D/3D heterostructure, [24] and functional additives. [12,[25][26][27] Among them, functional additives can simultaneously realize the modulation of the microstructure and defect compensation to obtain high-quality tin halide perovskite films.…”

One-Pot Chemobiocatalytic Production of 2,5-Bis(hydroxymethyl)furan and Its Diester from Biomass in Aqueous Media

“…Chemobiocatalysis integrating chemo- with biocatalysts in one pot is a promising protocol to synthesize value-added chemicals from inexpensive and readily available starting materials via multiple transformations − because of a number of advantages such as higher yields, improved overall synthetic efficiency and selectivity, and significantly reduced time, solvent consumption, and waste production. Despite being attractive, chemobiocatalytic transformations are highly challenging owing to mutual inactivation and incompatible issues between “different worlds” of catalysts in terms of solvents, pH, temperature, reagents, and so on. − To successfully construct chemobiocatalytic cascades for conversion of biomass to furan-based chemicals, it is critical to address biocatalyst inactivation issues.…”

Enhanced upgrading of corncob to furfuryl alcohol with a novel silica-supported SO42−-TiO2 chemocatalyst and immobilized whole-cell biocatalyst

“…One of the current research hotspots is chemoenzymatic cascades that convert lignocellulose into furan-based chemicals, like FFAC. 59 In this study, Brønsted/Lewis acid sites of the SO 4 2− -TiO 2 /SiO 2 solid acid system catalyzed the hemicellulose in biomass to synthesize FFA. The final FFA yield of 73.3% was achieved in aqueous system by using microwave heating.…”