Engineering Approaches for Breast Cancer Diagnosis: A Review

Kamal, Arif Mohd.; Sakorikar, Tushar; Pal, Uttam M.; Pandya, Hardik J.

doi:10.1109/rbme.2022.3181700

Cited by 11 publications

(3 citation statements)

References 161 publications

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“…Frozen section examination, used during intra-operative margin assessment, takes about 20 min per sample but is skill-intensive and subjective, requiring a high level of expertise from the pathologist, who also uses a high suspicion index to arrive at the conclusions [43]. While several technologies have been developed for non-invasive diagnostic breast imaging for identifying cancerous lesions and for intra-operative margin identification from large-sized excised ex vivo samples during surgical resection, advancements toward improving the analysis and diagnosis of ex vivo tissues extracted during biopsy (such as samples from core needle (CNB) and incisional biopsy) have been limited [44,45]. Most of the technologies available for diagnosing breast cancer from ex vivo tissues are compatible with analyzing only the largersized samples greater than 1 cm owing to the size of the equipment, the form factor of the probe, spatial resolution limitation, and power constraints [46][47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues

G. K.,

Gogoi,

Kachappilly

et al. 2023

J Biol Eng

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Background Technologies for quick and label-free diagnosis of malignancies from breast tissues have the potential to be a significant adjunct to routine diagnostics. The biophysical phenotypes of breast tissues, such as its electrical, thermal, and mechanical properties (ETM), have the potential to serve as novel markers to differentiate between normal, benign, and malignant tissue. Results We report a system-of-biochips (SoB) integrated into a semi-automated mechatronic system that can characterize breast biopsy tissues using electro-thermo-mechanical sensing. The SoB, fabricated on silicon using microfabrication techniques, can measure the electrical impedance (Z), thermal conductivity (K), mechanical stiffness (k), and viscoelastic stress relaxation (%R) of the samples. The key sensing elements of the biochips include interdigitated electrodes, resistance temperature detectors, microheaters, and a micromachined diaphragm with piezoresistive bridges. Multi-modal ETM measurements performed on formalin-fixed tumour and adjacent normal breast biopsy samples from N = 14 subjects were able to differentiate between invasive ductal carcinoma (malignant), fibroadenoma (benign), and adjacent normal (healthy) tissues with a root mean square error of 0.2419 using a Gaussian process classifier. Carcinoma tissues were observed to have the highest mean impedance (110018.8 ± 20293.8 Ω) and stiffness (0.076 ± 0.009 kNm−1) and the lowest thermal conductivity (0.189 ± 0.019 Wm−1 K−1) amongst the three groups, while the fibroadenoma samples had the highest percentage relaxation in normalized load (47.8 ± 5.12%). Conclusions The work presents a novel strategy to characterize the multi-modal biophysical phenotype of breast biopsy tissues to aid in cancer diagnosis from small-sized tumour samples. The methodology envisions to supplement the existing technology gap in the analysis of breast tissue samples in the pathology laboratories to aid the diagnostic workflow.

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Section: Discussionmentioning

confidence: 99%

Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues

G. K.,

Gogoi,

Kachappilly

et al. 2023

J Biol Eng

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“…Breast cancer in women has surpassed lung cancer as the most common cancer, with an estimated 2.3 million new cases (11.7%) ( 1 ). Breast cancer is a heterogeneous disease with multiple subtypes, each of which (Luminal type, HER2 + type, triple-negative breast cancer) all have unique clinical, pathological, and molecular features ( 2 , 3 ). HER2 is an epidermal growth factor receptor that is highly expressed in 20% of breast cancers ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Acute thrombocytopenia induced by trastuzumab due to complement reaction: A case report

Chen

et al. 2022

Front. Med.

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BackgroundThe usual treatment option for HER2 breast cancer is targeted therapy with trastuzumab. The common adverse effects of trastuzumab treatment are thrombocytopenia, however, acute thrombocytopenia is rare and its mechanism is still largely unknown.Case presentationWe reported a patient who presented with acute thrombocytopenia on two consecutive occasions, and the predisposing factor was identified on the second occasion because of trastuzumab-only treatment. Routine blood results showed a dramatic increase in white blood cell count and neutrophil count after both trastuzumab treatments. Moreover, the complement reaction results suggested that the dramatic thrombocytopenia was probably due to platelet destruction after complement activation.ConclusionThis case suggests that it would be useful to perform a platelet complement reaction test before trastuzumab treatment in patients with HER2 breast cancer.

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“…Goh et al [6] used a multispectral optoacoustic tomography system to quantify the breast cancer margin assessment. The photoacoustic system has also been used to differentiate the malignant tissue from the normal tissues by quantifying the melanin, oxygenated and deoxygenated haemoglobin [7]- [10]. Low-cost alternatives to photoacoustic imaging are gaining relevance in the scientific field, especially after the advent of low narrow-band and short-bandwidth LEDs [11].…”

Section: Introductionmentioning

confidence: 99%

Multiphysics simulation to mitigate critical design challenges of a photoacoustic system

Pal

2022

Optics in Health Care and Biomedical Optics XII

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With the advent of light-emitting diode (LED) increasingly used for Photoacoustic applications, it is imperative to mitigate the challenge of finding the most appropriate ultrasound transducer for a certain pulse excitation of the LED. The study aims to mitigate the challenge of finding the optimum operating frequency of the ultrasound required to detect the Photoacoustic signal while exciting the LED with a particular pulse input. The finite element method using COMSOL Multiphysics is implemented to perform a numerical model that fully couples electromagnetics, thermal, structural, mechanical, and acoustic physics. It is observed that as the pulse width of the LED excitation increases, the peak operating frequency of the ultrasound transducer also should increase. The operating frequency of the ultrasound transducer required for a particular pulse width of the excitation can be assessed using a finite element method approach.

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Engineering Approaches for Breast Cancer Diagnosis: A Review

Cited by 11 publications

References 161 publications

Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues

Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues

Acute thrombocytopenia induced by trastuzumab due to complement reaction: A case report

Multiphysics simulation to mitigate critical design challenges of a photoacoustic system

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