Engineering Antibody‐Based Therapeutics: Progress and Opportunities

Nguyen, Annalee W.; Maynard, Jennifer A.

doi:10.1002/9783527815128.ch13

Cited by 2 publications

(2 citation statements)

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“…Thus, an ideal target in antibody-based therapy should be a neoantigen that is expressed solely in tumor or diseased tissues and is shared among multiple patients. However, the discovery of such targets is still full of significant challenges . Of the relatively fewer antibody drugs that have been approved to target infectious diseases, as the antigens are generally exogenous, they are less likely to cause such life-threatening side effects.…”

Section: Is There a Place For Antibody-based Therapeutics?mentioning

confidence: 99%

“…However, the discovery of such targets is still full of significant challenges. 60 Of the relatively fewer antibody drugs that have been approved to target infectious diseases, as the antigens are generally exogenous, they are less likely to cause such life-threatening side effects. Nonetheless, other challenges remain to effectively identify susceptible targets in such diseases.…”

Section: The Rise Of Antibody-based Therapeuticsmentioning

confidence: 99%

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The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

et al. 2023

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The high selectivity and affinity of antibodies toward their antigens have made them a highly valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and genetic approaches have been devised to make antibodies accessible to more “undruggable” targets and equipped with new functions of illustrating or regulating biological processes more precisely. In this Review, in addition to introducing how naked antibodies and various antibody conjugates (such as antibody-drug conjugates, antibody-oligonucleotide conjugates, antibody-enzyme conjugates, etc.) work in therapeutic applications, special attention has been paid to how chemistry tools have helped to optimize the therapeutic outcome (i.e., with enhanced efficacy and reduced side effects) or facilitate the multifunctionalization of antibodies, with a focus on emerging fields such as targeted protein degradation, real-time live-cell imaging, catalytic labeling or decaging with spatiotemporal control as well as the engagement of antibodies inside cells. With advances in modern chemistry and biotechnology, well-designed antibodies and their derivatives via size miniaturization or multifunctionalization together with efficient delivery systems have emerged, which have gradually improved our understanding of important biological processes and paved the way to pursue novel targets for potential treatments of various diseases.

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Section: Is There a Place For Antibody-based Therapeutics?mentioning

confidence: 99%

Section: The Rise Of Antibody-based Therapeuticsmentioning

confidence: 99%