Engineering and Technologies Associated With Cardiac Valve Repair and Replacement Therapies

Sanchez, Jorge D. Zhingre; Bateman, Michael G.; Iaizzo, Paul A.

doi:10.1016/b978-0-12-813068-1.00009-9

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…This can aid in choosing the optimal size of the MV prosthetic device. The protrusion of the MV device into the LV can cause AML to move excessively towards the outflow tract, resulting in the formation of LVOT obstruction [36,37]. Our simulations demonstrated the capability of the developed model to simulate occlusion at the LVOT, by showing the effect of this obstruction on flow pattern and pressure gradient.…”

Section: Resultsmentioning

confidence: 70%

A 3D-0D Computational Model of the Left Ventricle for Investigating Blood Flow Patterns for Cases of Systolic Anterior Motion and after Anterior Mitral Leaflet Splitting

Alharbi

2024

Applied Sciences

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Valvular heart conditions significantly contribute to the occurrence of cardiovascular disease, affecting around 2–3 million people in the United States. The anatomical characteristics of cardiac muscles and valves can significantly influence blood flow patterns inside the ventricles. Understanding the interaction between the mitral valve and left ventricle structures enables using fluid–structure interaction simulations as a precise and user-friendly approach to investigating outcomes that cannot be captured using experimental approaches. This study aims to develop a 3D-0D computational model to simulate the consequences of extending the anterior mitral leaflet towards the left ventricle in the presence of the thickness of the left ventricular septum and the mitral valve device. The simulations presented in this paper successfully showcased the ability of the model to replicate occlusion occurring at the left ventricular outflow tract and illustrated the impact of this blockage on the flow pattern and pressure gradient. Furthermore, these simulations conducted following anterior mitral leaflet splitting can emphasize the significance of this technique in reducing the obstruction at the left ventricle outflow tract. The computational model presented in this study, combining 3D and 0D elements, provides significant insights into the flow patterns occurring in the left ventricle before and after anterior leaflet splitting. Thus, expanding this model can help explore other cardiac phenomena and investigate potential post-procedural complications.

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Section: Resultsmentioning

confidence: 70%

A 3D-0D Computational Model of the Left Ventricle for Investigating Blood Flow Patterns for Cases of Systolic Anterior Motion and after Anterior Mitral Leaflet Splitting

Alharbi

2024

Applied Sciences

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“…Additionally, the proximity of the aortic leaflet to the LVOT presents a high risk of LVOTO. One of the design strategies includes reducing stent protrusion into the ventricle, which may help to reduce the displacement of the anterior mitral leaflet toward the LVOT ( 56 ). Intrepid, for example, has a small device profile of 17 to 18 mm to minimize the risk of LVOTO ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review

Sazzad

Hon

Ramanathan

et al. 2022

Front. Cardiovasc. Med.

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The transcatheter mitral valve prosthesis is ideally suited for patients with inoperable mitral etiology. The transcatheter mitral valve implantation (TMVI) procedure has closely followed the evolution of transcatheter aortic procedures. There are considerable design variations amongst the limited TMVI prostheses currently available, and the implantation profiles of the devices are notably different. This comprehensive review will provide an overview of the current clinically tried TMVI devices with a focused outcome analysis. In addition, we have discussed the various design characteristics of TMVI and its associated failure mode, implantation technology, delivery methods, first-in-man trials, and pivotal trial summary for the synthesis of recent evidence.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021255241, identifier: CRD42021255241.

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The Anatomy and Function of the Atrioventricular Valves

et al. 2023

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Engineering and Technologies Associated With Cardiac Valve Repair and Replacement Therapies

Cited by 3 publications

References 30 publications

A 3D-0D Computational Model of the Left Ventricle for Investigating Blood Flow Patterns for Cases of Systolic Anterior Motion and after Anterior Mitral Leaflet Splitting

A 3D-0D Computational Model of the Left Ventricle for Investigating Blood Flow Patterns for Cases of Systolic Anterior Motion and after Anterior Mitral Leaflet Splitting

Design Variation, Implantation, and Outcome of Transcatheter Mitral Valve Prosthesis: A Comprehensive Review

The Anatomy and Function of the Atrioventricular Valves

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