Engineering a wolf spider A-family toxin towards increased antimicrobial activity but low toxicity
Ludwig Dersch,
Antonia Stahlhut,
Johanna Eichberg
et al.
Abstract:Peptides with insecticidal, antimicrobial and/or cytolytic activities, also known as spider venom antimicrobial peptides (AMPs), can be found in the venoms of RTA-clade spiders. They show translational potential as therapeutic leads. A set of 52 AMPs has been described in the Chinese wolf spider (Lycosa shansia), and many have been shown to exhibit antibacterial effects. Here we explored the potential to enhance their antimicrobial activity using bioengineering. We generated a panel of artificial derivatives o… Show more
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