Engineering a wirelessly self-powered and electroconductive scaffold to promote peripheral nerve regeneration

Yang, Yafeng; Yin, Xiaoxing; Wang, Huadong; Qiu, Wenqi; Li, Li; Li, Fenglu; Shan, Yizhu; Zhao, Ziteng; Li, Zhou; Guo, Ji-Ming; Zhang, Jin; Zhao, Yantao

doi:10.1016/j.nanoen.2022.108145

Cited by 26 publications

(29 citation statements)

References 33 publications

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“…Additionally, due to the strong penetrating ability of NIR light, Bi 2 S 3 /Ti 3 C 2 T x could be excited to generate photoelectrons . The conductive property of the nerve conduit facilitates the transmission of electrical signals, which is essential for nerve repair . Before the conductivity and photocurrent testing, the copper foil was pasted on both sides of the nerve conduit to reduce the influence of contact impedance. , The light-emitting diode (LED) lighting test experiment (Figure b) demonstrated that the Bi 2 S 3 /Ti 3 C 2 T x -PLLA conduit is conductive.…”

Section: Resultsmentioning

confidence: 99%

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Chen

et al. 2023

ACS Appl. Nano Mater.

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Bismuth sulfide (Bi2S3) enabled us to transform light signals into electrical signals via the photoelectric effect, which exhibited tremendous prospects on constructing wireless electrical stimulation for accelerating nerve regeneration. However, too rapid recombination of photogenerated electron–hole pairs weakened its photocurrent. Herein, the Bi2S3/Ti3C2T x heterojunction was synthesized by in situ growth of Bi2S3 nanoparticles on Ti3C2T x nanosheets and then mixed with poly-l-lactic acid (PLLA) powder to fabricate the Bi2S3/Ti3C2T x -PLLA conduit. At the heterojunction interfaces, Ti3C2T x with a more positive Fermi energy level could form interfacial potential difference with Bi2S3 to promote electron–hole pair separation. Meanwhile, Ti3C2T x with excellent conductivity could provide channels for photogenerated electron transmission, thus facilitating the generation of the photocurrent. Photoluminescence and electrochemical impedance spectroscopy analysis indicated that electron–hole pair separation and electron transfer were enhanced. As a consequence, under near-infrared light radiation, the output photocurrent of Bi2S3/Ti3C2T x -PLLA was increased from 0.48 to 1.43 μA compared to that of Bi2S3-PLLA. The enhanced photocurrent effectively promoted the differentiation of rat pheochromocytoma (PC12) into functional neurons by upregulating extracellular Ca2+ influx. Therefore, the above results demonstrated that this work provided a new perspective for wireless electrical stimulated nerve regeneration.

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Section: Resultsmentioning

confidence: 99%

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Chen

et al. 2023

ACS Appl. Nano Mater.

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“…Endogenous piezostimulation was shown to have critically important contribution to regeneration, as it was observed for the case of stimulated peripheral nerve regeneration. [52] While the effect of electrostimulation on human keratinocytes is well studied with clear evidence for promoted proliferation, differentiation, and migration, [53][54][55][56] the contribution of piezostimulation is widely unexplored. The detected response of HaCaT cells to US-mediated piezostimulation was a combination of a contribution of surface properties (chemistry, topography, and porosity), mechano-stimulation (cells-US interactions), and piezostimulation (electrical polarity-induced cell stimulation) (illustrated in Figure 8).…”

Section: Discussionmentioning

confidence: 99%

“…[62,63] US-mediated piezostimulation promoted cell differentiation, which formed aligned myotubes on patterned surfaces. [52] Extracellular stimulation of cells directly attached onto the PVDF piezoelectric surface has been observed to result in differentiated multipolar neural cells with extensive axon and dendrite formation, without alignment in the preferential direction. [64] Interestingly, in the case of piezoelectric PLLA films, US-mediated stimulation significantly increased actin filament formation specifically at the surface of highly oriented piezoelectric DR5 films.…”

Section: Discussionmentioning

confidence: 99%

Filler‐Enhanced Piezoelectricity of Poly‐L‐Lactide and Its Use as a Functional Ultrasound‐Activated Biomaterial

Vukomanović

Gazvoda

Kurtjak

et al. 2023

Small

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Poly‐L‐lactide (PLLA) offers a unique possibility for processing into biocompatible, biodegradable, and implantable piezoelectric structures. With such properties, PLLA has potential to be used as an advanced tool for mimicking biophysical processes that naturally occur during the self‐repair of wounds and damaged tissues, including electrostimulated regeneration. The piezoelectricity of PLLA strongly depends on the possibility of controlling its crystallinity and molecular orientation. Here, it is shown that modifying PLLA with a small amount (1 wt%) of crystalline filler particles with a high aspect ratio, which act as nucleating agents during drawing‐induced crystallization, promotes the formation of highly crystalline and oriented PLLA structures. This increases their piezoelectricity, and the filler‐modified PLLA films provide a 20‐fold larger voltage output than nonmodified PLLA during ultrasound (US)‐assisted activation. With 99% PLLA content, the ability of the films to produce reactive oxygen species (ROS) and increase the local temperature during interactions with US is shown to be very low. US‐assisted piezostimulation of adherent cells directly attach to their surface (such as skin keratinocytes), stimulate cytoskeleton formation, and as a result cells elongate and orient themselves in a specific direction that align with the direction of PLLA film drawing and PLLA dipole orientation.

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“…Recently, Yang et al presented a biohybrid hydrogel biomaterial, as shown in Figure 8c. [209] The hydrogel compounded with carbon nanotubes can provide endogenous piezoelectric stimulation and a conductive matrix that facilitates nerve bioelectric transport. Simultaneously, neural stem cells are mixed with GelMA hydrogel solution.…”

Section: Engineered Functional Biohybrid Hydrogels Laden With Living ...mentioning

confidence: 99%

Living cell‐laden hydrogels: Unleashing the future of responsive biohybrid systems

Hu,

Lei,

et al. 2023

Responsive Materials

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Responsive biohybrid systems have the potential to overcome limitations of both natural and artificial machines in terms of efficiency, accuracy, and functionality. As functional units, living cells act as bricks for building biohybrid machines, where the extracellular matrix mimics hydrogels to act as ideal biological concrete. Combining living cells with hydrogels offers unique advantages in simulating human tissues or organs, which unleashes the future of biohybrid systems, and thus has attracted extensive attention. Herein, recent progress in cell‐laden hydrogel‐based responsive biohybrid systems is summarized to provide a basic understanding of how these systems are built from the bottom up and how to achieve the complex functions. This review focuses on advanced manufacturing technologies for responsive biohybrid systems, including laden cells in hydrogel matrices, three‐dimensional bioprinting, and microfluidic manufacturing. Subsequently, the innovative applications of these works, including actuators, sensors, and engineered functional materials, are presented, along with different triggering mechanisms that are highlighted. Finally, the current challenges and future opportunities in the field are addressed. This review provides a unique perspective and is hoped to inspire fields such as biohybrid technologies, soft robots, and tissue engineering.

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Engineering a wirelessly self-powered and electroconductive scaffold to promote peripheral nerve regeneration

Cited by 26 publications

References 33 publications

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Filler‐Enhanced Piezoelectricity of Poly‐L‐Lactide and Its Use as a Functional Ultrasound‐Activated Biomaterial

Living cell‐laden hydrogels: Unleashing the future of responsive biohybrid systems

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Engineering a wirelessly self-powered and electroconductive scaffold to promote peripheral nerve regeneration

Cited by 26 publications

References 33 publications

Photoelectric Bi2S3 Nanoparticle/Ti3C2Tx Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Photoelectric Bi2S3 Nanoparticle/Ti3C2Tx Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Filler‐Enhanced Piezoelectricity of Poly‐L‐Lactide and Its Use as a Functional Ultrasound‐Activated Biomaterial

Living cell‐laden hydrogels: Unleashing the future of responsive biohybrid systems

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Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth