Abstract:Synthetic
red fluorescent protein (RFP) chromophores have emerged
as valuable tools for biological imaging and therapeutic applications,
but their application in the visualization of endogenous RNA G-quadruplexes
(G4s) in living cells has been rarely reported so far. Here, by integrating
the group of the excellent G4 dye ThT, we modulate RFP chromophores
to create a novel fluorescent probe DEBIT with red emission. DEBIT
selectively recognizes the G4 structure with the advantage of strong
binding affinity, high… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.