Engineering a novel immunogenic chimera protein utilizing bacterial infections associated with atherosclerosis to induce a deviation in adaptive immune responses via Immunoinformatics approaches

Saleki, Kiarash; Alijanizade, Parsa; Moradi, Saead; Rahmani, Abolfazl; Banazadeh, Mohammad; Mohamadi, Mohamad Hosein; Shahabi, Farzad; Nouri, Hamid Reza

doi:10.1016/j.meegid.2022.105290

Cited by 14 publications

(8 citation statements)

References 63 publications

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“…In silico methods may be useful for the rapid design and development of immunotherapeutics. [21][22][23] The alloy used in the foreign object may be important in the development of different immune reactions. Titanium alloy and stainless-steel alloy group implantation influence TLR-4 pathways and CD4 + CD25 + T reg -cells in various ways.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, one novel approach to target immune reactions to the implants and accidentally left pieces of neurosurgical tools is to target immunological elements that mediate inflammatory processes, such as toll‐like receptors (TLRs), inflammasomes, and adaptive immune system components. In silico methods may be useful for the rapid design and development of immunotherapeutics 21–23 . The alloy used in the foreign object may be important in the development of different immune reactions.…”

Section: Discussionmentioning

confidence: 99%

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Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Zali,

Herfedoust Biazar,

Saleki

et al. 2023

Clinical Case Reports

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Key Clinical MessageLumbar spinal stenosis (LSS) is a prevalent cause of leg and back pain. In the youth, LSS is not common and mainly results from hereditary musculoskeletal disorders. Moreover, spinal fusion is a surgical approach to the treatment of LSS. Entrapment of surgical tools due to breakage is a rare yet important phenomenon in such operations. Therefore, neurological sequelae of these events need to be explored. The case was a 24‐year‐old male complaining of local back pain. Initially, he was diagnosed with LSS at L4 and L5. After the fusion of the vertebrae by the posterior spinal fusion (PSF) method, the patient's pain was resolved. However, the subject complained of worsening local back pain limiting his ability to do routine tasks. A few years later, radiographical evaluations indicated the possible presence of a surgical tool that could not be removed via surgery. During a third operation, the object was removed, and the patient's symptoms recovered. Immediate removal of entrapped surgical objects is necessary due to risks associated with migration and central nervous system damage. Comparing our results to other similar reports, we conclude that in cases of foreign object entrapment, neurological sequelae may be nonexistent or progressively worsen. Also, sequelae emerge either soon after the operation or emerge later. This complicates the diagnosis of such events and the decision of whether to subject the patient to additional neurosurgical operations to remove the tool. These variations may be observed due to the moving of the entrapped tool. Follow‐up of neurological sequelae in spinal surgery patients is recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Zali,

Herfedoust Biazar,

Saleki

et al. 2023

Clinical Case Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…The overall quality score calculated by ProSA for a special input construct is shown in a graph that indicates the scores of every experimentally quantified protein structure accessible in the Protein Data Bank (PDB) [ 22 ]. ERRAT ProCheck is another tool that scores amino acids in 9-residue intervals [ 4 , [23] , [24] , [25] , [26] ]. The quality of the modeled protein was verified by Ramachandran plot, ProSA, and UCLA SAVES 6 analyses ( Supplementary material ).…”

Section: Methodsmentioning

confidence: 99%

Matrix metalloproteinase/Fas ligand (MMP/FasL) interaction dynamics in COVID-19: An in silico study and neuroimmune perspective

Saleki,

Aram,

Alijanizadeh

et al. 2024

Heliyon

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“…These immune elements modulate hyperinflammation and significantly contribute to neurological disorders. Immunoinformatics could help to develop immune-mediating therapeutics to this aim rapidly against CNS disorders ( Saleki et al, 2022a , Rahmani et al, 2021 , Saleki et al, 2022c , Saleki et al, 2022d ).…”

Section: Insight For the Futurementioning

confidence: 99%

Engineering a novel immunogenic chimera protein utilizing bacterial infections associated with atherosclerosis to induce a deviation in adaptive immune responses via Immunoinformatics approaches

Cited by 14 publications

References 63 publications

Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Surgical tool entrapment in a young patient with recurrent lumbar spinal stenosis: a case report

Matrix metalloproteinase/Fas ligand (MMP/FasL) interaction dynamics in COVID-19: An in silico study and neuroimmune perspective

Deep brain stimulation (DBS) as a therapeutic approach in gait disorders: What does it bring to the table?

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