Engineering a novel antibacterial agent with multifunction: Protocatechuic acid-grafted-quaternized chitosan

Zhou, Chen; Ao, Haiyong; Han, Xiao; Jiang, Wenwen; Yang, Zhi-Fei; Ma, Le; Deng, Xiaoyan; Wan, Yizao

doi:10.1016/j.carbpol.2021.117683

Cited by 40 publications

(14 citation statements)

References 46 publications

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“…Additionally, and alternatively, particles may be immobilized after obtaining the fibers, via entrapment between the fiber yarns and/or physical/chemical attachment to the fibers [ 177 ]. The immobilization of plant-extract-loaded CS-based organic particles onto fibers, fibrous assemblies, and textile fabrics can occur via three main types of chemical bonds, similarly as described elsewhere for the case of biomolecule’s immobilization onto natural fibers [ 54 ]: (a) physical adsorption, (b) physical entrapment, and (c) covalent bonding.…”

Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

“…On the other hand, the immobilization method trends of the aforementioned particles include the dip-pad-dry-cure method, impregnation, exhaustion method, spray-drying, and covalent chemistry. The goal is to immobilize a sufficient number of compounds in the fibrous templates, giving them enough bioactivity, for the necessary time period [ 54 , 161 ].…”

Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

“…As communicable diseases threaten to reach epidemic proportions, affecting patients from all ages, societal and financial status, with high mortality rates and healthcare burden, the search for effective antimicrobial strategies is highly needed. In parallel, plant extracts (widely used as folk medicine) are increasingly considered as potential alternatives to antibiotics, having high potential for being a source of natural drugs that can be used to counteract microbial survival and prosperity [ 22 , 54 , 55 ]. Several natural drugs have already been approved for clinical use, namely for antioxidant and antimicrobial purposes [ 178 , 179 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings. On the other hand, renewable plant-derived extracts are here emphasized, given their potential as eco-friendly radical scavengers, microbicidal agents, or alternatives to antibiotics, considering that most of the latter have induced bacterial resistance because of excessive and/or inappropriate use. Loading them into small-scaled particles potentiates a strong and sustained bioactivity, and a controlled release, using lower doses of bioactive compounds. A pH-triggered release, dependent on CS’s protonation/deprotonation of its amine groups, has been the most explored stimulus for that control. However, the use of CS derivatives, crosslinking agents, and/or additional stabilization processes is enabling slower release rates, following extract diffusion from the particle matrix, which can find major applicability in fiber-based systems within ROS-enriched microenvironments and/or spiked with microbes. Research on this is still in its infancy. Yet, the few published studies have already revealed that the composition, along with an adequate drug release rate, has an important role in controlling an existing infection, forming new tissue, and successfully closing a wound. A bioactive finishing of textiles has also been promoting high particle infiltration, superior washing durability, and biological response.

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Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

Section: Biomedical Applications: Fiber-based Systemsmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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“…Protocatechuic acid (PCA) is a catechol-like molecule with mixed antioxidant, anti-inflammatory and antiproliferative effects [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], probably due to its fairly simple structure and the consequent multi-target and off-target interactions [ 22 ]. Similar to other natural compounds, these multi-modal, sometimes “opposite” effects could be related to a state-dependent activity.…”

Section: Introductionmentioning

confidence: 99%

Ethyl Protocatechuate Encapsulation in Solid Lipid Nanoparticles: Assessment of Pharmacotechnical Parameters and Preliminary In Vitro Evaluation for Colorectal Cancer Treatment

et al. 2023

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Colorectal cancer is one of the most diffused tumoral diseases. Since most medicaments employed for its treatment are debilitating, the use of naturally derived products, which can be effective against the mutated cells and, in addition, can reduce most inflammatory-related effects, could be extremely beneficial for the continued treatment of this disease. In this research, ethyl protocatechuate (PCAEE), a protocatechuic acid prodrug, was encapsulated in solid lipid nanoparticles (SLN) (prepared without and with Tween 80), which were characterized in terms of size, polydispersity index (PDI), zeta potential and thermotropic behavior. Encapsulation efficiency, release profile and interaction with a model of biomembrane were also assessed. The nanoparticles were tested in vitro on both healthy cells and on a model of tumoral cells. SLN prepared with Tween 80 was promising in terms of physicochemical properties (z-average of 190 nm, PDI 0.150 and zeta potential around −20 mV) and encapsulation efficiency (56%); they showed a desirable release profile, demonstrated an ability to penetrate and release the encapsulated PCAEE into a biomembrane model and were nontoxic on healthy cells. In addition, they caused a greater dose-dependent decrease in the viability of CaCo-2 cells than PCAEE alone. In conclusion, the formulation could be proposed for further studies to assess its suitability for the treatment of colorectal cancer.

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“…There have been a number of studies regarding to the chemical modification of CS and the organic-inorganic composites. 13,14 Focusing on the improvement of antibacterial activity and broad-spectrum of CS, several researches had tried to introduce kinds of small molecules with high antibacterial activity into CS structure, such as quaternary ammonium salt modification, 15 tea polyphenol modification, 16 protocatechuic modification, 13 geraniol modification, 17 curcumin modification, 18 lysine modification, 19 and so on. In our previous research, hinokitiol-grafted-chitosan (HTCS) was prepared and its MIC values against S. aureus and E. coli achieved the lower values 43 and 54 μg/mL, respectively.…”

Section: Introductionmentioning

confidence: 99%

High antibacterial and antioxidant cotton fabric based on AgNPs@HTCS and hyaluronic acid via lay by lay self-assembly

Luo

Liu

Wang

et al. 2022

Journal of Industrial Textiles

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The fabrics of health care function have drawn increasing attention. Herein, AgNO3 was in-situ reduced into nano silver (AgNPs) by aloe extract (AVE) as reducing agent to gain AgNPs@hinokitiol-grafted chitosan (AgNPs@HTCS). The antibacterial and antioxidant cotton fabric were fabricated by LBL method using AgNPs@HTCS as positive layer and hyaluronic acid as negative layer. The results showed that the optimum preparation conditions of AgNPs@HTCS were as follows: AgNO3 10 mmol/L, HTCS 40 v/v %, AVE 15 mL, 80 °C, 6 h. MIC values of AgNPs@HTCS against S. aureus and E. coli attained 1.7 μg/mL and 5.3 μg/mL, respectively. The antibacterial ratio of cotton fabric reached the maximum 99.9 % at very low concentration of AgNPs@HTCS 0.25 g/L. After 3 LBL layers, the antibacterial properties of functional cotton fabric could withstand the acid or alkali washing. After 25 washing cycles, the antibacterial rate of LBL fabric still maintained above 96 %. Compared with the untreated fabric, antioxidant capacity of LBL functional cotton fabric raised approximately two times. LBL functional cotton fabric still retained the wear performances of the original fabric.

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Engineering a novel antibacterial agent with multifunction: Protocatechuic acid-grafted-quaternized chitosan

Cited by 40 publications

References 46 publications

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

Ethyl Protocatechuate Encapsulation in Solid Lipid Nanoparticles: Assessment of Pharmacotechnical Parameters and Preliminary In Vitro Evaluation for Colorectal Cancer Treatment

High antibacterial and antioxidant cotton fabric based on AgNPs@HTCS and hyaluronic acid via lay by lay self-assembly

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