Engineering a New IFN-ApoA-I Fusion Protein with Low Toxicity and Prolonged Action
Svetlana Miroshnichenko,
Mariya Pykhtina,
Anastasiia Kotliarova
et al.
Abstract:Recombinant human interferon alpha-2b (rIFN) is widely used in antiviral and anticancer immunotherapy. However, the high efficiency of interferon therapy is accompanied by a number of side effects; this problem requires the design of a new class of interferon molecules with reduced cytotoxicity. In this work, IFN was modified via genetic engineering methods by merging it with the blood plasma protein apolipoprotein A-I in order to reduce acute toxicity and improve the pharmacokinetics of IFN. The chimeric prot… Show more
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