Engineering a durable BDDE cross-linked collagen filler for skin rejuvenation
Qi Wang,
Huiyu Yan,
Jingting Zhang
et al.
Abstract:Skin aging, characterized by reduced regeneration, chronic inflammation, and heightened skin cancer risk, poses a significant challenge. Collagen fillers have emerged as a potential solution for skin rejuvenation by stimulating collagen regeneration. However, their clinical efficacy is limited by inherent instability and vulnerability to in vivo degradation by collagenase. Chemical cross-linking presents a promising approach to enhance stability, but it carries risks such as cytotoxicity, calcification, and di… Show more
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