Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art

Chintamaneni, Pavan Kumar; Nagasen, Dasari; Babu, Katta Chanti; Mourya, Atul; Madan, Jitender; Srinivasarao, Dadi A.; Ramachandra, R.; Santhoshi, P. Madhuri; Pindiprolu, Sai Kiran S. S.

doi:10.1016/j.jconrel.2022.10.056

Cited by 11 publications

(6 citation statements)

References 189 publications

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“…The tablets pass the USP test if there are no more than two tablets that are greater than the percentage limit or less than two times the percentage limit. 17 To solve this problem the official compendial specifications are mentioned below in Table 2.…”

Section: Weight Variationmentioning

confidence: 99%

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Dasari,

Phani Kumar,

Gummadi

et al. 2024

Ind. J. Pharm. Edu. Res

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Objectives:The objective of this study was to develop a stable and effective form of an Orodispersible tablet containing Nicardipine Hydrochloride for the immediate treatment of high blood pressure and angina. The aim was to achieve this by using the natural sweetener stevia to improve taste. Background: Nicardipine Hydrochloride is used to treat high blood pressure and angina. However, currently available immediate release forms have limitations in terms of drug release and taste. Therefore, the goal was to develop an Orodispersible form of the drug that would enhance drug release and improve taste masking capabilities. Materials and Methods: We developed formulations of Nicardipine Hydrochloride Orodispersible tablets using the natural sweetener Stevia rebaudiana to enhance taste and reduce the caustic sensation. We confirmed the compatibility of the drug-excipient mixture using FTIR. Drug content and dissolution were determined through UV spectrophotometry. We also conducted organoleptic tests and other compendial specification tests. Precompression parameters were evaluated, and measures were taken to improve the flow behavior of the formulation blend by using excipients with excellent flow properties. Based on disintegration and dissolution time, we selected the F6 formulation as the optimized formula. We then subjected the developed trial to stability studies for three months, evaluating disintegration time, drug content, and dissolution. Results: The optimized formulation demonstrated a disintegration time of 46.25±0.85 sec and a dissolution rate of 100.50±2.50. Compendial tests remained stable without any significant fluctuations after the stability study. Also, the taste of the drug was pleasant after taste. Conclusion: Through the appropriate selection of excipients, we successfully developed a stable and effective form of Nicardipine Hydrochloride Orodispersible tablet with enhanced drug release (using the solid dispersion technique) and improved taste masking capabilities. The optimized formulation yielded favorable results in terms of disintegration and dissolution time, drug content, and stability.

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Section: Weight Variationmentioning

confidence: 99%

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Dasari,

Phani Kumar,

Gummadi

et al. 2024

Ind. J. Pharm. Edu. Res

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“…24 On the other hand, unlike traditional fluorescent agents, UCNPs can convert near-infrared (NIR) radiation into tunable shorter wavelength luminescence, thus avoiding background signal noise from samples and the surroundings. 25 NIR light penetrates deeper than visible light, and it can induce UCNPs to produce luminescence from UCNPs in deeper tissues, showing significant potential for in vivo imaging. 26 As a result, UCNPs hold great promise for multifunctional drug delivery and biomedical imaging applications.…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy

Kou

Nie

et al. 2023

Nanoscale

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“…The interest in these nanostructures originates from their chemical stability, their low toxicity, and their ability to produce narrow, differentiable peaks with a strong emission in several spectral regions, especially in the near-infrared (NIR) range of the electromagnetic spectrum with its transparency windows [3]. These windows (also referred to as biological windows) range from 680-950 nm (NIR-I) and 1000-1350 nm (NIR-IIa) and allow researchers to achieve unique penetration of light into tissues [4][5][6]. Taking advantage of these characteristics helped to increase the biological applications of RENPs for non-invasive real-time imaging of cells and tissues [7].…”

Section: Introductionmentioning

confidence: 99%

Eosin Y-Functionalized Upconverting Nanoparticles: Nanophotosensitizers and Deep Tissue Bioimaging Agents for Simultaneous Therapeutic and Diagnostic Applications

López-Peña

Simón-Fuente

Ortgies

et al. 2022

Cancers

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Functionalized upconverting nanoparticles (UCNPs) are promising theragnostic nanomaterials for simultaneous therapeutic and diagnostic purposes. We present two types of non-toxic eosin Y (EY) nanoconjugates derived from UCNPs as novel nanophotosensitizers (nano-PS) and deep-tissue bioimaging agents employing light at 800 nm. This excitation wavelength ensures minimum cell damage, since the absorption of water is negligible, and increases tissue penetration, enhancing the specificity of the photodynamic treatment (PDT). These UCNPs are uniquely qualified to fulfil three important roles: as nanocarriers, as energy-transfer materials, and as contrast agents. First, the UCNPs enable the transport of EY across the cell membrane of living HeLa cells that would not be possible otherwise. This cellular internalization facilitates the use of such EY-functionalized UCNPs as nano-PS and allows the generation of reactive oxygen species (ROS) under 800 nm light inside the cell. This becomes possible due to the upconversion and energy transfer processes within the UCNPs, circumventing the excitation of EY by green light, which is incompatible with deep tissue applications. Moreover, the functionalized UCNPs present deep tissue NIR-II fluorescence under 808 nm excitation, thus demonstrating their potential as bioimaging agents in the NIR-II biological window.

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Engineered upconversion nanocarriers for synergistic breast cancer imaging and therapy: Current state of art

Cited by 11 publications

References 189 publications

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine Hydrochloride Orodispersable Tablets for Rapid Absorption

Erythrocyte membrane-camouflaged DNA-functionalized upconversion nanoparticles for tumor-targeted chemotherapy and immunotherapy

Eosin Y-Functionalized Upconverting Nanoparticles: Nanophotosensitizers and Deep Tissue Bioimaging Agents for Simultaneous Therapeutic and Diagnostic Applications

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