Engineered Stem Cell-Based Scaffolds and Patches for Heart Disorders

Newman, Jamie J.; Patel, Nehal R.; Caldorera‐Moore, Mary

doi:10.1007/978-3-319-20726-1_5

Cited by 1 publication

(1 citation statement)

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“…Poly (glycerol sebacate) (PGS) was first discovered in 2002 as a novel biodegradable polymer (Wang et al., 2002) and has since become increasingly utilized in a variety of biomedical applications (Newman et al., 2016; Sun et al., 2009; Yi‐Cheun et al., 2016). To date, the synthesis of TEVGs from poly (glycerol sebacate) PGS has relied on the use of sacrificial inner mandrels that are eventually removed to produce a tubular graft (Crapo et al., 2008; Gao et al., 2006; Kemppainen & Hollister, 2010).…”

Section: Introductionmentioning

confidence: 99%

Extruded poly (glycerol sebacate) and polyglycolic acid vascular graft forms a neoartery

Fukunishi

Lui

Ong

et al. 2022

J Tissue Eng Regen Med

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In the ongoing search for the optimal biomaterial for tissue engineered vascular grafts (TEVGs), poly (glycerol sebacate) (PGS) has emerged as a new potential candidate. We have utilized a novel method to create unique, pore‐free, extruded PGS grafts with and without a supportive exterior layer of polyglycolic acid (PGA). The 1 mm diameter by 5 mm length TEVGs were implanted in a rat model of infrarenal abdominal aorta interposition grafting. Three months after implantation, TEVGs comprised of extruded PGS with an external PGA braid demonstrated a patency rate of 9/10 (90%) with no signs of dilatation, dehiscence, or rupture. The PGS/PGA graft was remodeled into a neoartery with complete endothelialization of the neoartery lumen and formation of smooth muscle actinin multilayers as demonstrated via immunohistochemistry. Formation and maturation of extracellular matrix material were also observed, with amounts of elastin and collagen comparable to native rat aorta. No significant host inflammatory response was observed. These findings suggest the combination of an extruded PGS tube with an external reinforcing PGA braid is a promising material for small diameter TEVGs.

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