Engineered silica nanoparticles are biologically safe vehicles to deliver drugs or genes to liver cells

Tüncel, Özge; Kahraman, Erkan; Bağcı, Gülsün; Atabey, Neşe; Özçelik, Serdar

doi:10.1016/j.msec.2020.111585

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Both the temperature and time used during this process vary considerably between the procedures followed by different research groups. 16,[32][33][34] In this work, the mildest possible conditions were used. Specically, pure silica nanoparticles were synthesized based on the Stöber method described by Zhou et al (2014), 16 as shown in Scheme 1.…”

Section: Nanoparticles Synthesismentioning

confidence: 99%

Hybrid organic–inorganic nanoparticles with associated functionality for catalytic transformation of biomass substrates

2023

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Section: Nanoparticles Synthesismentioning

confidence: 99%

Hybrid organic–inorganic nanoparticles with associated functionality for catalytic transformation of biomass substrates

2023

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“…These engineered SiNPs involve intentional modifications and designs aimed at enhancing their properties and functionalities. [ 53 ] Through precise engineering, the surface chemistry, size, shape, and charge of SiNPs can be customized to meet the specific requirements of different nucleic acid delivery and various applications. [ 54 ] Additionally, SiNPs with modified compositions have demonstrated improved application performance compared to their unmodified counterparts.…”

Section: Silica Nanoparticles Designed For Nucleic Acid Delivery Appl...mentioning

confidence: 99%

Engineered Silica Nanoparticles for Nucleic Acid Delivery

Zhang,

Yu,

Yang

et al. 2023

Small Methods

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The development of nucleic acid‐based drugs holds great promise for therapeutic applications, but their effective delivery into cells is hindered by poor cellular membrane permeability and inherent instability. To overcome these challenges, delivery vehicles are required to protect and deliver nucleic acids efficiently. Silica nanoparticles (SiNPs) have emerged as promising nanovectors and recently bioregulators for gene delivery due to their unique advantages. In this review, a summary of recent advancements in the design of SiNPs for nucleic acid delivery and their applications is provided, mainly according to the specific type of nucleic acids. First, the structural characteristics and working mechanisms of various types of nucleic acids are introduced and classified according to their functions. Subsequently, for each nucleic acid type, the use of SiNPs for enhancing delivery performance and their biomedical applications are summarized. The tailored design of SiNPs for selected type of nucleic acid delivery will be highlighted considering the characteristics of nucleic acids. Lastly, the limitations in current research and personal perspectives on future directions in this field are presented. It is expected this opportune review will provide insights into a burgeoning research area for the development of next‐generation SiNP‐based nucleic acid delivery systems.

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“…Therefore, they are considered as biologically safe carriers to deliver drugs or genes. 70 Recently, many works have been reported and developed for cancer treatment. There are still many challenges in cancer treatment, such as the affected site or organ in the body, side effects to the non-diseased cell, and drug delivery to cancer cells.…”

Section: Silica-based Nanomaterials In Drug-delivery and Biomedical A...mentioning

confidence: 99%

“…Although the promising properties of functionalized silica nanoparticles (SiO 2 NPs) as a biosafe delivery platform for drugs and genes have been established, their abilities as a carrier of target cancer cells may be developed more by decorating its solid surface with antibody fragments or peptides. 70…”

Section: Silica-based Nanomaterials and Its Applicationsmentioning

confidence: 99%