Engineered Porphyrin Loaded Core-Shell Nanoparticles for Selective Sonodynamic Anticancer Treatment

Varchi, Greta; Foglietta, Federica; Canaparo, Roberto; Ballestri, Marco; Arena, Francesca; Sotgiu, Giovanna; Guerrini, Andrea; Nanni, Cristina; Cicoria, Gianfranco; Cravotto, Giancarlo; Fanti, Stefano; Serpe, Loredana

doi:10.2217/nnm.15.150

Cited by 60 publications

(58 citation statements)

References 39 publications

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“…For efficient SDT, it is required that the positioning of tumor tissue for US irradiation is of great significance because US should be focused precisely on the therapeutic target. This work indicates that the sonosensitizer is potentially engineered as the concurrent contrast agents for diagnostic imaging and synergistic agents for SDT (theranostic function), which can further realize the diagnostic imaging‐guided SDT with concurrently high safety and efficiency …”

Section: Organic Micro/nanoparticles‐augmented Sonosensitizermentioning

confidence: 91%

“…The easy functionalization of porphyrin molecule endows them with new functionality, such as diagnostic‐imaging performance. As a paradigm, Mn (III) and 64 Cu was coordinated into TPPS molecules for contrast‐enhanced MR imaging and positron emission tomography (PET), respectively . TPPS, Mn(III)‐TPPS and 64 Cu‐TPPS were further encapsulated into polymethyl methacrylate NPs (PMMA NPs), respectively.…”

Section: Organic Micro/nanoparticles‐augmented Sonosensitizermentioning

confidence: 99%

“…Photosensitizers such as porphyrin derivatives or photoactive nanoparticles (NPs) are typically employed, which can be triggered to generate cytotoxic reactive oxygen species (ROS) to induce the cell apoptosis and necrosis, including radicals of hydroxyl (OH•)/peroxy radicals (HO 2 •) and non‐radical singlet oxygen ( 1 O 2 ) . These ROS species can cause the cell damage by peroxidizing the lipid membrane, disrupting DNA/proteins and/or destroying the signal functions/gene transcription . PDT has been extensively investigated because it is featured with low toxicity to normal cell/tissue where only the light‐activated region can generate toxic ROS.…”

Section: Introductionmentioning

confidence: 99%

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Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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The fast development of photoactivation for cancer treatment provides an efficient photo-therapeutic strategy for cancer treatment, but traditional photodynamic or photothermal therapy suffers from the critical issue of low in vivo penetration depth of tissues. As a non-invasive therapeutic modality, sonodynamic therapy (SDT) can break the depth barrier of photoactivation because ultrasound has an intrinsically high tissue-penetration performance. Micro/nanoparticles can efficiently augment the SDT efficiency based on nanobiotechnology. The state-of-art of the representative achievements on micro/nanoparticle-enhanced SDT is summarized, and specific functions of micro/nanoparticles for SDT are discussed, from the different viewpoints of ultrasound medicine, material science and nanobiotechnology. Emphasis is put on the relationship of structure/composition-SDT performance of micro/nanoparticle-based sonosensitizers. Three types of micro/nanoparticle-augmented SDT are discussed, including organic and inorganic sonosensitizers and micro/nanoparticle-based but sonosensitizer-free strategies to enhance the SDT outcome. SDT-based synergistic cancer therapy augmented by micro/nanoparticles and their biosafety are also included. Some urgent critical issues and potential developments of micro/nanoparticle-augmented SDT for efficient cancer treatment are addressed. It is highly expected that micro/nanoparticle-augmented SDT will be quickly developed as a new and efficient therapeutic modality which will find practical applications in cancer treatment. At the same time, fundamental disciplines regarding materials science, chemistry, medicine and nanotechnology will be advanced.

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Section: Organic Micro/nanoparticles‐augmented Sonosensitizermentioning

confidence: 91%

Section: Organic Micro/nanoparticles‐augmented Sonosensitizermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

2016

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“…To solve this problem, the most common strategy to improve the sensitization effect of SDT is to conjugate nanoparticles with organic sonosensitizers. For instance, Canaparo and co‐workers loaded meso‐tetrakis (4‐sulfophenyl) porphyrins in polymethyl methacrylate nanoparticles to enhance the yield of ROS . Chen et al anchored protoporphyrin in the mesoporous silica nanoparticles for the better accumulation of the sonosensitizers in the tumor .…”

Section: Methodsmentioning

confidence: 99%

Metal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy

et al. 2018

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Sonodynamic therapy (SDT) can overcome the critical issue of depth-penetration barrier of photo-triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal-organic-framework (MOF)-derived carbon nanostructure that contains porphyrin-like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production. The nanoparticle-assisted cavitation process, including the visualized formation of the cavitation bubbles and microjets, is also first captured by high-speed camera. High ROS production in PMCS under ultrasound is validated by electron spin resonance and dye measurement, followed by cellular destruction and high tumor inhibition efficiency (85%). This knowledge is important from the perspective of understanding the structure-dependent SDT enhancement of a MOF-derived carbon nanostructure.

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“…HESW treatment also increased tumor uptake of the loaded drug, with associated growth reduction. 187 Lithotripsy continues to find some application for sonodynamic therapy research, 188,189 where ultrasound is required primarily for 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 28 drug activation rather than delivery, but is not a commonly used ultrasound-mediated delivery technique for chemotherapy, and no references could be found for the combination of HESW, cisplatin and nanoparticles.…”

Section: Lithotripsymentioning

confidence: 99%

Drug Delivery Strategies for Platinum-Based Chemotherapy

Browning

Reardon²,

Parhizkar³

et al. 2017

ACS Nano

196

129

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Few chemotherapeutics have had such an impact on cancer management as cis-diamminedichloridoplatinum(II) (CDDP), also known as cisplatin. The first member of the platinum-based drug family, CDDP's potent toxicity in disrupting DNA replication has led to its widespread use in multidrug therapies, with particular benefit in patients with testicular cancers. However, CDDP also produces significant side effects that limit the maximum systemic dose. Various strategies have been developed to address this challenge including encapsulation within micro- or nanocarriers and the use of external stimuli such as ultrasound to promote uptake and release. The aim of this review is to look at these strategies and recent scientific and clinical developments.

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Engineered Porphyrin Loaded Core-Shell Nanoparticles for Selective Sonodynamic Anticancer Treatment

Cited by 60 publications

References 39 publications

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Metal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy

Drug Delivery Strategies for Platinum-Based Chemotherapy

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