Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface

Simpson, Joshua D.; Smith, Samuel A.; Thurecht, Kristofer J.; Such, Georgina K.

doi:10.3390/polym11091441

Cited by 25 publications

(35 citation statements)

References 230 publications

(313 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significant advancement in nanotechnology made possible the production and designing of multifunctional hybrid biomaterials that are highly appropriate for biomedical applications [1]. The development of magnetically engineered colloids is of great interest because of their unique properties and has emerged as promising functional tools for bioapplications for simultaneous diagnostic and therapeutic (theranostic) purposes.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Khizar

Ahmad

Saleem³

et al. 2020

Advances in Polymer Technology

View full text Add to dashboard Cite

A stable oil-in-water (O/W) magnetic emulsion was prepared by the emulsification of organic ferrofluid in an aqueous media, and its theranostic applications were investigated. The synthesis and characterization of the organic ferrofluid were carried out comprising of superparamagnetic maghemite nanoparticles with oleic acid coating stabilized in octane. Both exhibit spherical morphology with a mean size of 6 nm and 200 nm, respectively, as determined by TEM. Thermogravimetric analysis was carried out to determine the chemical composition of the emulsion. The research work described here is novel and elaborates the fabrication of thin-film gradients with 5, 10, 15, and 20 bilayers by layer-by-layer technique using polydimethyl diallyl ammonium chloride (PDAC) and prepared magnetic colloidal particles. The thin-film gradients were characterized for their roughness, morphology, and wettability. The developed gradient films and colloids were explored in magnetic resonance imaging (MRI) and hyperthermia. T1- and T2-weighted images and their corresponding signal intensities were obtained at 1.5 T. A decreasing trend in signal intensities with an increase in nanoparticle concentration in colloids and along the gradient was observed in T2-weighted images. The hyperthermia capability was also evaluated by measuring temperature rise and calculating specific absorption rates (SAR). The SAR of the colloids at 259 kHz, 327 kHz, and 518 kHz were found to be 156 W/g, 255 W/g, and 336 W/g, respectively. The developed magnetic combinatorial thin-film gradients present a significant potential for the future efficient simultaneous diagnostic and therapeutic bioapplications.

show abstract

Section: Introductionmentioning

confidence: 99%

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Khizar

Ahmad

Saleem³

et al. 2020

Advances in Polymer Technology

View full text Add to dashboard Cite

show abstract

“…Over the last few decades, advancements in the field of nanotechnology and material sciences have led to a major breakthrough in the fabrication of various NMs composed of DNA ( Dai et al, 2017 ; Jiang et al, 2017 ), polymers ( Chang et al, 2018 ; Simpson et al, 2019 ), carbon ( Teradal and Jelinek, 2017 ; Jiang et al, 2019 ), metals ( Dhivya et al, 2015 ; Singh, 2018 ), composites ( Song et al, 2015 ; Zhai et al, 2018 ), liposomes ( Zhang et al, 2011 ; Lorente et al, 2018 ; Zhang et al, 2018 ), et cetera for cancer therapy. Synthesis of NMs allows the materials to be fine-tuned to tailor their properties (e.g., size, composition, surface properties, etc.)…”

Section: Mechanism Of Immunomodulation By Nanomaterialsmentioning

confidence: 99%

Nanomaterials-Mediated Immunomodulation for Cancer Therapeutics

2021

View full text Add to dashboard Cite

Immunotherapy holds great promise in overcoming the limitations of conventional regimens for cancer therapeutics. There is growing interest among researchers and clinicians to develop novel immune-strategies for cancer diagnosis and treatment with better specificity and lesser adversity. Immunomodulation-based cancer therapies are rapidly emerging as an alternative approach that employs the host’s own defense mechanisms to recognize and selectively eliminate cancerous cells. Recent advances in nanotechnology have pioneered a revolution in the field of cancer therapy. Several nanomaterials (NMs) have been utilized to surmount the challenges of conventional anti-cancer treatments like cytotoxic chemotherapy, radiation, and surgery. NMs offer a plethora of exceptional features such as a large surface area to volume ratio, effective loading, and controlled release of active drugs, tunable dimensions, and high stability. Moreover, they also possess the inherent property of interacting with living cells and altering the immune responses. However, the interaction between NMs and the immune system can give rise to unanticipated adverse reactions such as inflammation, necrosis, and hypersensitivity. Therefore, to ensure a successful and safe clinical application of immunomodulatory nanomaterials, it is imperative to acquire in-depth knowledge and a clear understanding of the complex nature of the interactions between NMs and the immune system. This review is aimed at providing an overview of the recent developments, achievements, and challenges in the application of immunomodulatory nanomaterials (iNMs) for cancer therapeutics with a focus on elucidating the mechanisms involved in the interplay between NMs and the host’s immune system.

show abstract

“…Due to the flow-based design, microfluidics-based platforms are inherently suitable for breast cancer metastasis study. Microfluidics offers one of the only means for mimicking vascular conditions and controlling specific factors such as flow rate experimentally ( Simpson et al, 2019 ). Through regulation of the flow perfusion, microfluidic assays enable quantitative analysis of diverse biological processes in high-resolution.…”

Section: The Breast Tumor Microenvironmentmentioning

confidence: 99%

Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis

Sigdel

Gupta

Faizee

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Of around half a million women dying of breast cancer each year, more than 90% die due to metastasis. Models necessary to understand the metastatic process, particularly breast cancer cell extravasation and colonization, are currently limited and urgently needed to develop therapeutic interventions necessary to prevent breast cancer metastasis. Microfluidic approaches aim to reconstitute functional units of organs that cannot be modeled easily in traditional cell culture or animal studies by reproducing vascular networks and parenchyma on a chip in a three-dimensional, physiologically relevant in vitro system. In recent years, microfluidics models utilizing innovative biomaterials and micro-engineering technologies have shown great potential in our effort of mechanistic understanding of the breast cancer metastasis cascade by providing 3D constructs that can mimic in vivo cellular microenvironment and the ability to visualize and monitor cellular interactions in real-time. In this review, we will provide readers with a detailed discussion on the application of the most up-to-date, state-of-the-art microfluidics-based breast cancer models, with a special focus on their application in the engineering approaches to recapitulate the metastasis process, including invasion, intravasation, extravasation, breast cancer metastasis organotropism, and metastasis niche formation.

show abstract

Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio–Nano Interface

Cited by 25 publications

References 230 publications

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Magnetic Colloidal Particles in Combinatorial Thin-Film Gradients for Magnetic Resonance Imaging and Hyperthermia

Nanomaterials-Mediated Immunomodulation for Cancer Therapeutics

Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis

Contact Info

Product

Resources

About