Engineered photoresponsive biohybrids for tumor therapy

Wang, Xiaocheng; Sun, Yukun; Wangpraseurt, Daniel

doi:10.1002/smmd.20220041

Cited by 4 publications

(1 citation statement)

References 200 publications

(713 reference statements)

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“…In 2006, El-Sayed synthesized Gold nanorod with a large aspect ratio with an intense near-infrared absorption peak and further exhibited its potentials in killing cancer cells . Since then, a wide variety of photothermal materials of organic, inorganic, , polymetric, and biological nature − have been developed and exploited in proof-of-concept in vivo therapeutic applications. Other inorganic materials also found wide applications in PTT including Prussian blue, quantum dots, metal oxide nanoparticles, black phosphorus, and nanocarbon materials.…”

Section: Introductionmentioning

confidence: 99%

Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy

Lu,

Yin,

Zhuang

et al. 2024

Ind. Eng. Chem. Res.

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Organic chromophores, especially those absorbing/ emitting in the deep near-infrared region (deep-NIR, i.e., 800 nm and beyond), have prominent potentials in photothermal cancer therapy due to the deep tissue penetration and good biocompatibility. Although many cyanine/DAD-based photothermal agents have been successfully used in clinical and preclinical trials, they are limited to poor photostability and poor molar absorptivity. There is still an imperative demand for robust deep-NIR photothermal agents exhibiting high photostability and high molar absorptivity. We previously invented a bright push−pull fluorochromic scaffold (EC5) absorbing and emitting in the deep-NIR spectral region. In this work, EC5 was rationally tailored to suppress its fluorescence emission and promote its photothermal conversion efficiency. This led to the design and synthesis of EC5PM and EC5DP by changing two or four of its N-alkyl groups of the push−pull headgroups of EC5 into phenyl groups, respectively. The fluorescence intensities of EC5PM and EC5DP are completely quenched due to the TICT effect associated with the N−Ph bonds. In particular, EC5DP maximally absorbs at a longer wavelength of 879 nm with a superior photostability, a high photothermal conversion efficiency of 54.8%, and a superior molar extinction coefficient of 224,000 M −1 cm −1 . Upon encapsulation in DSPE-mPEG2000 micelles, the phototoxicity of EC5DP was showcased in 4T1 cells and a remarkable therapeutic effect of tumors was showcased with a 4T1 tumor-bearing mouse model. This work provides a rational strategy to design ultraphotostable and highly deep-NIR absorbing organic chromophores for photothermal therapy.

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Section: Introductionmentioning

confidence: 99%

Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy

Lu,

Yin,

Zhuang

et al. 2024

Ind. Eng. Chem. Res.

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Photothermal Responsive Microcarriers Encapsulated With Cangrelor and 5‐Fu for Colorectal Cancer Treatment

Yang,

Wang,

Fan

et al. 2023

Small Methods

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Localized chemotherapy is emerging as a potential strategy for cancer treatment due to its low systemic toxicity. However, the immune evasion of tumor cells and the lack of an intelligent design of the delivery system limit its clinical application. Herein, photothermal responsive microcarriers are designed by microfluidic electrospray for colorectal tumor treatment. The microcarriers loaded with Cangrelor, 5‐FU and MXene (G‐M@F/C+NIR) show sustained delivery of antiplatelet drug Cangrelor, thus inhibiting the activity of platelets, interactions of platelet‐tumor cell, as well as the tumor cells invasion and epithelial‐mesenchymal transition (EMT). In addition, the sustained delivery of chemotherapeutics 5‐FU and the photothermal effect provided by MXene enable the microcarriers to inhibit tumor cells proliferation and migration. In vivo studies validate that the G‐M@F/C+NIR microcarriers significantly inhibites tumor growth, decreased the expression of Ki‐67 in tumor cells and vascular endothelial growth factor (VEGF) in the tumor microenvironment, while increased the expression of E‐cadherin. It is believe that by means of the proposed photothermal responsive microcarriers, the synergistic strategy of platelet inhibition, chemotherapy, and photothermal therapy can find practical applications in cancer treatment.

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Biomimetic cascade-released hydrogel scaffolds from microfluidics for efficient T cell recruitment and expansion

Shou,

Wu,

Chen

et al. 2024

Chemical Engineering Journal

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Engineered photoresponsive biohybrids for tumor therapy

Cited by 4 publications

References 200 publications

Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy

Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy

Photothermal Responsive Microcarriers Encapsulated With Cangrelor and 5‐Fu for Colorectal Cancer Treatment

Biomimetic cascade-released hydrogel scaffolds from microfluidics for efficient T cell recruitment and expansion

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