Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing

Trementozzi, Andrea N.; Leung, Cheuk-Yui; Osei-Yeboah, Frederick; Irdam, Erwin; Lin, Yiqing; MacPhee, James; Boulas, Pierre; Karki, Shyam; Zawaneh, Peter N.

doi:10.1016/j.ijpharm.2017.03.011

Cited by 18 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adequate powder flowability should be maintained for high speed tableting and encapsulation processes [10]. The use of glidants have become quite common for most of the pharmaceutical industries in order to reduce the issues of powder agglomeration and to maintain the powder flowability [11]. However, it has been reported that excess use of glidants may disturb the surface morphology and decrease the solubility properties of the drugs thus affecting the hardness range of the tablets [12].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

An investigation into the flowability of fine powders used in pharmaceutical industries

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Accepted Manuscriptmentioning

confidence: 99%

An investigation into the flowability of fine powders used in pharmaceutical industries

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This can be achieved by spherical crystallization methods [1]. Spherical morphology provides suitable powder rheological properties for the API, thus flow time, angle of repose, bulk density, compressibility and compactibility improve, which ensures good tabletability with reduced amounts of additives [9].…”

Section: Importance Of Spherical Crystallizationmentioning

confidence: 99%

On-line observation of the crystal growth in the case of the non-typical spherical crystallization methods of ambroxol hydrochloride

Gyulai

Aigner

2018

Powder Technology

View full text Add to dashboard Cite

Spherical agglomeration (SA) of four products was observed by the focused beam reflectance measurement (FBRM), conclusions, similarities, differences were summarized and the agglomeration mechanism was revealed.  The same was performed in the case of cooling crystallization with an alternating temperature profile (ATP) as well.  Crystallization types were compared in case of using a double-walled glass reactor of 250 ml with a total solvent volume of 80 ml and, as a scale-up, a jacketed reactor of 750 ml with a total solvent volume of 500 ml, while applying different types of agitation.  The effect of the addition of more cycles to the ATP methods was investigated. Light microscopic exposures prove significant differences between the SA and the ATP products.

show abstract

“…This makes the stress walk (SW), practically, one of the most attractive methods for material flow characterization using shear cell and that is, evidenced by its use in recent studies on powder flow. 9,12,15 Notable among them is the generation of 9-point flow functions by this method in the preshear normal stress range of 0.25-15 kPa. In fact, this method can be used in any stress range accessible to the new ring shear tester.…”

Section: Introductionmentioning

confidence: 99%

Impact of Shear History on Powder Flow Characterization Using a Ring Shear Tester

Swize

Osei-Yeboah

Peterson

et al. 2019

Journal of Pharmaceutical Sciences

Self Cite

View full text Add to dashboard Cite

In this study, we have investigated the impact of repeated shear displacement on powder flow properties. We show that when multiple yield loci are obtained using the same bulk solid specimen by stepping through different stress levels (i.e., stress walk [SW]), the shear deformation of the powder in a rotational shear cell, that is, Schulze Ring Shear Tester, is maximized, reducing the powder shear strength. This approach is material and time sparing; however, it imprecisely predicts better powder flowability. The magnitude of the change in the unconfined yield strength, σ, due to this prolonged shear displacement appears to be material-dependent, being less impactful for free-flowing powders. Using the SW and the individual yield loci-generated flow properties, we have demonstrated that in hopper design, the shear displacement effect impacts the computed critical arching diameter more than the critical mass flow angle. This knowledge of powder flow properties highlights limitations associated with the SW. An exponential function was found to describe the relationship between the change in σ at the highest major principal stress and the density weighted flowability, ff, with an R of 0.98. Such a model could be a valuable tool for correcting shear strength results obtained from SW, saving time, and material.

show abstract

Engineered particles demonstrate improved flow properties at elevated drug loadings for direct compression manufacturing

Cited by 18 publications

References 28 publications

An investigation into the flowability of fine powders used in pharmaceutical industries

An investigation into the flowability of fine powders used in pharmaceutical industries

On-line observation of the crystal growth in the case of the non-typical spherical crystallization methods of ambroxol hydrochloride

Impact of Shear History on Powder Flow Characterization Using a Ring Shear Tester

Contact Info

Product

Resources

About