Engineered optoplasmonic core-satellite microspheres for SERS determination of methamphetamine derivative and its precursors

Contactless and robust dielectric microspheres-assisted surface-enhanced Raman scattering sensitivity improvement for anthrax biomarker detection

“…The Raman signal of rhodamine 6G molecules measured in presence of DMs was up to seven times larger than that measured using a flat silver film alone ( Wang et al, 2019 ). A uniform raspberry-like nanostructure composed of noble metal nanoparticles (Au n or Ag n ) and silica particles (80 or 100 nm) was synthesized by taking the advantage of well-studied electrostatic attractions ( Hong et al, 2022 ). Recently, a sandwich structure was designed by immobilizing polymethyl methacrylate (PMMA) microspheres, self-assembling silver nanoparticles (AgNPs), and depositing SiO 2 microspheres.…”

Fabrication of an Optoplasmonic Raft with Improved SERS Performance Detecting Methamphetamine through Bubble Enrichment

“…By applying the formula LOD = 3σ/ m and LOQ = 10σ/ m , where σ is the standard deviation of the blank and m is the fitted slope, , the level of LOD for METH stands at 0.035 nM and the limit of quantification (LOQ) stands at 0.28 nM (Figure c). The developed substrate with bubbling strategy demonstrates outstanding sensitivity and holds compatibility with portable SERS devices …”

“…The optoplasmonic structure, embracing low-loss channel modes, efficiently transmits optical energy and thus excites stronger LSPR, which leads to extraordinary E-field enhancement effects . Combining different structural morphologies with the photonic–plasmonic interaction, optoplasmonic structures enable SERS substrates with excellent detecting performance and other features, including agglomeration resistance. , Common designs of optoplasmonic structures include dielectric resonators combined with noble metal NPs in the periphery of the photonic modes. , The inherent optoplasmonic interaction between the LSPR particles and the dielectric spheres provides amplified E-field intensity and therefore brings improved detection performance of SERS. − However, due to the dispersed nature of the system, these hybrid particles suffer from complicated manual handling in collection and assembly. Currently, optoplasmonic SERS substrates with a relatively large area for specific detection conditions are necessary for practical applications.…”

Interpol Review of Drug Analysis 2019-2022

“…2019 LC-MS/MS determination of content and dissolution profiles of MDMA tablets [ 196 ]; characterization of seized ecstasy tablets using GC-MS and UV spectroscopy, and a method using IR spectroscopy to first differentiate ecstasy from other party drugs and further quantify MDMA in the tablets. The study included a comparison between NIR and Mid-IR spectroscopy in combination with partial least squares-discriminant analysis (PLS-DA) and-regression (PLS) [ 197 ]; 2020 application of 3D printed tools for ESI-MS analysis of MDMA/MDEA in homemade pills [ 198 ]; electrochemical method for MDMA detection in seized samples [ 199 ]; 2021 electrochemical sensor detect MDMA by Linear Sweep Voltammetry in aqueous medium [ 200 ]; investigation of the 3D structure of MDMA in solution by vibrational circular dichroism and electronic circular dichroism supplemented by conventional IR and ultraviolet absorption spectroscopies [ 201 , 202 ]; MDMA-related mortality trends across Australia, Finland, Portugal and Turkey [ 203 ]; 2022 method validation for the quantification of MDMA in tablets based on the United Nations Office on Drugs and Crime (UNODC) guideline for quantitative NMR (qNMR) [ 204 ]; SERS sensing of MDMA and the corresponding precursors including safrole and piperonal [ 205 ]; quantitative analysis of 302 substances suspected by police to contain MDMA and seized at New South Wales music festivals between October 2019 and March 2020 [ 206 ]; development of a method for the detection of MDMA in latent fingerprints using surface plasmon resonance and lateral flow technology [ 207 ].…”