Engineered nasal dry powder for the encapsulation of bioactive compounds

Baldelli, Alberto; Boraey, Mohammed A.; Oğuzlu, Hale; Cidem, Aylin; Rodríguez, Athenea Pascual; Ong, Hui Xin; Jiang, Feng; Bacca, Mattia; Thamboo, Andrew; Traini, Daniela; Pratap‐Singh, Anubhav

doi:10.1016/j.drudis.2022.04.012

Cited by 28 publications

(17 citation statements)

References 89 publications

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“…For example, aerogel particles obtained by spraying with the described parameters can be used to create nasal delivery systems, since their aerodynamic characteristics allow them to be deposited in the nasal cavity. Aerogel particles obtained by the homogenization method with the selected parameters have a smaller aerodynamic diameter and therefore can be used for inhalation delivery [ 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Chitosan Aerogel Particles as Nasal Drug Delivery Systems

Menshutina

Majouga

Uvarova

et al. 2022

Gels

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The nasal drug delivery route has distinct advantages, such as high bioavailability, a rapid therapeutic effect, non-invasiveness, and ease of administration. This article presents the results of a study of the processes for obtaining chitosan aerogel particles that are promising as nasal or inhalation drug delivery systems. Obtaining chitosan aerogel particles includes the following steps: the preparation of a chitosan solution, gelation, solvent replacement, and supercritical drying. Particles of chitosan gels were obtained by spraying and homogenization. The produced chitosan aerogel particles had specific surface areas of up to 254 m2/g, pore volumes of up to 1.53 cm3/g, and porosities of up to 99%. The aerodynamic diameters of the obtained chitosan aerogel particles were calculated, the values of which ranged from 13 to 59 µm. According to the calculation results, a CS1 sample was used as a matrix for obtaining the pharmaceutical composition “chitosan aerogel—clomipramine”. X-ray diffraction (XRD) analysis of the pharmaceutical composition determined the presence of clomipramine, predominantly in an amorphous form. Analysis of the high-performance liquid chromatography (HPLC) data showed that the mass loading of clomipramine was 35%. Experiments in vivo demonstrated the effectiveness of the pharmaceutical composition “chitosan aerogel—clomipramine” as carrier matrices for the targeted delivery of clomipramine by the “Nose-to-brain” mechanism of nasal administration. The maximum concentration of clomipramine in the frontal cortex and hippocampus was reached 30 min after administration.

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Section: Resultsmentioning

confidence: 99%

“…The study [ 36 ] showed that the optimal particle size of nasal dry sprays to ensure the greatest adhesion to the mucous membrane was a diameter of 50–100 µm. It was noted that particles with a diameter of less than 20 microns can provide delivery to the lungs, so such particles can be used to create inhaled drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Aerogel Particles as Nasal Drug Delivery Systems

Menshutina

Majouga

Uvarova

et al. 2022

Gels

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“…The scope of application of such material for a particular case determines the size of the aerogel particles. Thus, for the development of drug-loaded compositions for nasal applications based on peptides, for example, a range of particle sizes of 10–45 microns may be optimal [ 7 ]. For oral delivery, for example, carriers of vitamin supplements, particles in a wide range of sizes from nanometers to several centimeters may be required [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Adsorption from a solution is the easiest way to load a drug into an aerogel. In this method, the aerogel is immersed in a solution of a drug of a certain concentration for a time [ 7 , 31 , 33 ]. The aerogel begins to absorb the drug from the solution, which allows for the achievement of sufficiently high concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…It is important to note that, in order to deliver the drug by the “Nose-to-brain” mechanism, it is necessary that the drug settles on the olfactory area of the nasal cavity [ 36 ]. To do this, the carrier matrix must have a certain aerodynamic diameter (from 50 to 100 microns) [ 7 ]. Due to the possibility of directional control of characteristic and particle size of aerogels, as well as their low density and high porosity, it is possible to achieve this goal.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems

Lovskaya

Bezchasnyuk

Mochalova

et al. 2022

Gels

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The research was oriented towards the preparation of aerogel particles based on egg white and whey protein isolate using various dispersion methods: dripping, spraying, and homogenization. Based on the results of analytical studies, the most appropriate samples were selected to obtain aerogels loaded with the drug. The results of the experimental research were used to study methods for obtaining nasal drug delivery systems based on aerogels. Protein aerogels were obtained by thermal gelation followed by supercritical drying. The obtained particles of protein aerogels have a specific surface area of up to 350 m2/g with a pore volume of up to 2.9 cm3/g, as well as a porosity of up to 95%. The results of experimental studies have shown that changing the dispersion method makes it possible to control the structural characteristics of protein aerogel particles. The results of the studies were applied to obtain innovative nasal drug delivery systems for the treatment of socially significant diseases. Analytical studies were conducted to determine the amount and state of adsorbed drugs in protein aerogel particles, as well as in vivo experiments on the distribution of clomipramine in blood plasma and brain tissue of rats to study the pharmacokinetics and bioavailability of the resulting drug-loaded protein aerogel.

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Inhibition of Metal-Polyphenol Complex in Tea Fortified with Encapsulated Iron

Baldelli,

Arrieta,

Pratap-Singh

2024

Food Bioprocess Technol

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Fortifying tea with iron faces the formation of a blue complex between iron and polyphenols. These technical challenges were circumvented by encapsulating iron sulphate with walls of whey proteins and Eudraguard via spray drying. Three types of capsules were generated based on the quantity of enclosed iron, 5.1, 7.7, or 10.0 mg; the quantity of iron is proportional to the complex formation. The encapsulation process enhanced iron absorption by 73% compared to free iron. The iron-polyphenol complex formation in gallic acid and black tea solution was studied. The complex formation in two buffers, 2-(N-Morpholino)ethane sulfonic acid (MES), and [piperazine-N, N′-bis(2-ethanesulfonic acid)] (PIPES), in two pH, 5.5 and 6.6, and the situations of buffered and unbuffered gallic acid in 0.3 mM ferrous sulphate solution was analyzed. The most stable solutions were gained with gallic acid in MES at pH 5.5 and 6.6 and PIPES at 6.6.

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Engineered nasal dry powder for the encapsulation of bioactive compounds

Cited by 28 publications

References 89 publications

Chitosan Aerogel Particles as Nasal Drug Delivery Systems

Chitosan Aerogel Particles as Nasal Drug Delivery Systems

Preparation of Protein Aerogel Particles for the Development of Innovative Drug Delivery Systems

Inhibition of Metal-Polyphenol Complex in Tea Fortified with Encapsulated Iron

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