Engineered nanosponges as versatile biodegradable carriers: An insight

Jain, Ankit; Prajapati, Shiv Kumar; Kumari, Anita; Mody, Nishi; Bajpai, Meenakshi

doi:10.1016/j.jddst.2020.101643

Cited by 48 publications

(45 citation statements)

References 106 publications

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“…Moreover, 3D printing techniques are now being considered to ease the production of NS. Different routes and modes of drug administration e.g., aerosols, capsules, parenteral, tablets, topicals are now being exhausted for NS delivery [11].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Polymeric Nanosponge Hydrogel for Terbinafine Hydrochloride: Statistical Optimization, In Vitro and In Vivo Studies

et al. 2020

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Terbinafine hydrochloride, although one of the prominent antifungal agents, suffers from low drug permeation owing to its hydrophobic nature. The approach of nanosponge formulation may thus help to resolve this concern. Thus, the present research was envisioned to fabricate the nanosponge hydrogel of terbinafine hydrochloride for topical delivery since nanosponge augments the skin retentivity of the drug. The optimized formulation was obtained using Box Behnken Design. The dependent and independent process parameters were also determined wherein polyvinyl alcohol (%), ethylcellulose (%), and tween 80 (%) were taken as independent process parameters and particle size, polydispersity index (PDI), and entrapment efficiency (EE) were the dependent parameters. The nanosponge was then incorporated into the hydrogel and characterized. In-vitro drug release from the hydrogel was 90.20 ± 0.1% which was higher than the drug suspension and marketed formulation. In vitro permeation potential of the developed formulation through rat skin showed a flux of 0.594 ± 0.22 µg/cm2/h while the permeability coefficient was 0.059 ± 0.022 cm/s. Nanosponge hydrogel was evaluated for non-irritancy and antifungal activity against C. albicans and T. rubrum confirming the substantial outcome. Tape stripping studies exhibited ten times stripping off the skin quantified 85.6 ± 0.21 μg/cm2. The confocal analysis justified the permeation potential of the prepared hydrogel. The mean erythemal score was 0.0, confirming that the prepared hydrogel did not cause erythema or oedema. Therefore, based on results obtained, nanosponge hydrogel formulation is a potential carrier for efficient topical delivery of terbinafine hydrochloride.

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Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Polymeric Nanosponge Hydrogel for Terbinafine Hydrochloride: Statistical Optimization, In Vitro and In Vivo Studies

et al. 2020

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“…Nanosponges have drawn the interest of drug delivery scientists in pharmaceutical science as they have the capacity to load both hydrophilic and lipophilic moieties [61,62]. These are thin, non-toxic, porous colloidal structures of scaffolds that have multiple cavities where drug molecules can be stuck.…”

Section: Nanospongesmentioning

confidence: 99%

Nanomedicines: Nano based Drug Delivery Systems Challenges and Opportunities

Hamid¹,

Manzoor²

2021

Alternative Medicine - Update

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Nanomedicine and nano delivery systems, although relatively recent but fast-developing technology is one where nanoscale materials are used to function as diagnostic tools or to deliver therapeutic agents to specifically targeted sites in a controlled manner. It also provides many advantages in the management of human diseases. Recently, there has been a range of excellent uses of nanomedicine as chemotherapeutic agents, biological agents, immunotherapeutic agents, etc., for treatment of different diseases. In this chapter we discuss the recent developments and insights obtained in the field of nanomedicine. It provides a review of the numerous nano-based drug delivery systems that enhance the efficacy of new and old drugs. The new opportunities and challenges arising in the area of nanomedicine from therapeutic viewpoint are also addressed.

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“…• In cancer targeting NSs based mostly drug delivery systems are with been successfully developed as a result of it releases the drug specifically at the tumor site, shows additional impact at a given dose. As a smaller quantity of the drug comes in contact in grips with healthy tissue thus this shows fewer aspect effects [41].…”

Section: Merits Of Nssmentioning

confidence: 99%