Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma

Luo, Lijia; Iqbal, M. Zubair; LIU, Chuang; Xing, Jie; Akakuru, Ozioma Udochukwu; Fang, Qianlan; Li, Zihou; Dai, Yunlu; Li, Aiguo; Guan, Yong; Wu, Aiguo

doi:10.1016/j.biomaterials.2019.119464

Cited by 87 publications

(49 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[25] Subsequent literatures mentioned that the mechanism of Fe 3 O 4 NPs polarized macrophages was based on the Fenton reaction. [26][27][28][29] Although these studies speculate that Fenton reaction promotes TAMs polarization, there is no more in-depth study to prove this process. At the same time, it was also pointed out that the accumulation of iron in the macrophages could cause the phenotypic switching since Fe 3 O 4 NPs could be internalized by macrophages and degraded to iron ions.…”

Section: The Progress Of Antitumor Immunotherapy Is Usually Limited Bmentioning

confidence: 99%

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Liu

Wang

Guo

et al. 2020

Small

View full text Add to dashboard Cite

The progress of antitumor immunotherapy is usually limited by tumor‐associated macrophages (TAMs) that account for the highest proportion of immunosuppressive cells in the tumor microenvironment, and the TAMs can also be reversed by modulating the M2‐like phenotype. Herein, a biomimetic polymer magnetic nanocarrier is developed with selectively targeting and polarizing TAMs for potentiating immunotherapy of breast cancer. This nanocarrier PLGA‐ION‐R837 @ M (PIR @ M) is achieved, first, by the fabrication of magnetic polymer nanoparticles (NPs) encapsulating Fe3O4 NPs and Toll‐like receptor 7 (TLR7) agonist imiquimod (R837) and, second, by the coating of the lipopolysaccharide (LPS)‐ treated macrophage membranes on the surface of the NPs for targeting TAMs. The intracellular uptake of the PIR @ M can greatly polarize TAMs from M2 to antitumor M1 phenotype with the synergy of Fe3O4 NPs and R837. The relevant mechanism of the polarization is deeply studied through analyzing the mRNA expression of the signaling pathways. Different from previous reports, the polarization is ascribed to the fact that Fe3O4 NPs mainly activate the IRF5 signaling pathway via iron ions instead of the reactive oxygen species‐induced NF‐κB signaling pathway. The anticancer effect can be effectively enhanced through potentiating immunotherapy by the polarization of the TAMs in the combination of Fe3O4 NPs and R837.

show abstract

Section: The Progress Of Antitumor Immunotherapy Is Usually Limited Bmentioning

confidence: 99%

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Liu

Wang

Guo

et al. 2020

Small

View full text Add to dashboard Cite

show abstract

“…The role of MONPs in immunotherapy is rapidly emerging. For instance, iron oxide NPs that have been approved by the Food and Drug Administration (FDA) modulate MФ activity and show promising results in cancer immunotherapy [65]. Since metals may exhibit both pro- or anti-inflammatory effects in a context-dependent but hardly controllable way, NPs are often loaded with particular cytokines to control MФ profiles.…”

Section: Therapeutic Applications Of Nanoparticle-macrophage Intermentioning

confidence: 99%

Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions

et al. 2019

View full text Add to dashboard Cite

Macrophages are components of the innate immune system that control a plethora of biological processes. Macrophages can be activated towards pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes depending on the cue; however, polarization may be altered in bacterial and viral infections, cancer, or autoimmune diseases. Metal (zinc, iron, titanium, copper, etc.) oxide nanoparticles are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools. Macrophages can recognize and engulf nanoparticles, while the influence of macrophage-nanoparticle interaction on cell polarization remains unclear. In this review, we summarize the molecular mechanisms that drive macrophage activation phenotypes and functions upon interaction with nanoparticles in an inflammatory microenvironment. The manifold effects of metal oxide nanoparticles on macrophages depend on the type of metal and the route of synthesis. While largely considered as drug transporters, metal oxide nanoparticles nevertheless have an immunotherapeutic potential, as they can evoke pro- or anti-inflammatory effects on macrophages and become essential for macrophage profiling in cancer, wound healing, infections, and autoimmunity.

show abstract

“…Nanoparticles have become a promising strategy for anti-cancer treatment due to their inherent properties. To date, the clinical approvals for tumor therapy are organic materials, including liposomes (pegylated or non-pegylated) and albumin, while inorganic materials are used for tracking and molecular imaging functions, and only superparamagnetic iron oxide (SPIO) nanoparticles are approved in clinical (1). Nanoparticles for tumor therapy are mainly used for drug delivery, photothermal therapy, modification and preparation of engineered cells, imaging diagnosis, and lymph node (LN) tracing.…”

Section: Introductionmentioning

confidence: 99%

Anti-Cancer Nanomedicines: A Revolution of Tumor Immunotherapy

Peng

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

Immunotherapies have been accelerating the development of anti-cancer clinical treatment, but its low objective responses and severe off-target immune-related adverse events (irAEs) limit the range of application. Strategies to remove these obstacles primarily focus on the combination of different therapies and the exploitation of new immunotherapeutic agents. Nanomedicine potentiates the effects of activating immune cells selectively and reversing tumor induced immune deficiency microenvironment through multiple mechanisms. In the last decade, a variety of nano-enabled tumor immunotherapies was under clinical investigation. As time goes by, the advantages of nanomedicine are increasingly prominent. With the continuous development of nanotechnology, nanomedicine will offer more distinctive perspectives in imaging diagnosis and treatment of tumors. In this Review, we wish to provide an overview of tumor immunotherapy and the mechanisms of nanomaterials that aim to enhance the efficacy of tumor immunotherapy under development or in clinic treatment.

show abstract

Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma

Cited by 87 publications

References 31 publications

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions

Anti-Cancer Nanomedicines: A Revolution of Tumor Immunotherapy

Contact Info

Product

Resources

About