Engineered Multifunctional Nanocarriers for Cancer Diagnosis and Therapeutics

Shi, Donglu; Bedford, Nicholas M.; Cho, Hoonsung

doi:10.1002/smll.201100436

Cited by 97 publications

(65 citation statements)

References 153 publications

(155 reference statements)

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“…The demand for a new delivery system comes from the onset of these new formulations of drugs, and it is necessary to identify possible ways to solve some of the shortfalls of the current treatment regimen (Shapira et al 2011). Therefore, nanoparticles, as targeted carriers of drugs, are being developed as alternative non-biological carriers to meet these challenges (Shi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects

2011

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Magnetic nanoparticles (MNPs) represent a subclass within the overall category of nanomaterials and are widely used in many applications, particularly in the biomedical sciences such as targeted delivery of drugs or genes, in magnetic resonance imaging, and in hyperthermia (treating tumors with heat). Although the potential benefits of MNPs are considerable, there is a distinct need to identify any potential toxicity associated with these MNPs. The potential of MNPs in drug delivery stems from the intrinsic properties of the magnetic core combined with their drug loading capability and the biomedical properties of MNPs generated by different surface coatings. These surface modifications alter the particokinetics and toxicity of MNPs by changing protein-MNP or cell-MNP interactions. This review contains current advances in MNPs for drug delivery and their possible organ toxicities associated with disturbance in body iron homeostasis. The importance of protein-MNP interactions and various safety considerations relating to MNP exposure are also addressed.

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Section: Introductionmentioning

confidence: 99%

Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects

2011

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“…It is widely known that the Fenton process involves the generation of hydroxyl radicals (·OH) as the major oxidizing species and ·HO 2 as the minor oxidizing species, which may be described by Reactions (1), (2) and (3) …”

Section: Science China Materialsmentioning

confidence: 99%

“…Several recent studies have demonstrated the potential of these materials in the development of multifunctional probes with both imaging and therapeutic capabilities [1,2]. In particular, superparamagnetic iron oxide nanoparticles have been successfully used as delivery platforms for bioseparation, magnetic drug delivery, and magnetic resonance imaging (MRI) contrast agents, as well as for magnetic hyperthermia of tumor treatment [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles

Yang

Cui

et al. 2015

Sci. China Mater.

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Engineered iron oxide magnetic nanoparticles (MNPs) are one of the most promising tools in nanomedicine-based diagnostics and therapy. However, increasing evidence suggests that their specific delivery efficiency and potential long-term cytotoxicity remain a great concern. In this study, using 12 nm γ-Fe2O3 MNPs, we investigated three types of uptake pathways for MNPs into HepG2 cells: (1) a conventional incubation endocytic pathway; (2) MNPs co-administrated with microbubbles under ultrasound exposure; and (3) ultrasound delivery of MNPs covalently coated on the surface of microbubbles. The delivery efficiency and intracellular distribution of MNPs were evaluated, and the cytotoxicity induced by reactive oxygen species (ROS) was studied in detail. The results show that MNPs can be delivered into the lysosomes via classical incubation endocytic internalization; however, microbubbles and ultrasound allow the MNPs to pass through the cell membrane and enter the cytosol via a non-internalizing uptake route much more evenly and efficiently. Further, these different delivery routes result in different ROS levels and antioxidant capacities, as well as intracellular glutathione peroxidase activity for HepG2 cells. Our data indicate that the microbubble-ultrasound treatment method can serve as an efficient cytosolic delivery strategy to minimize long-term cytotoxicity of MNPs.

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“…4,6 Multifarious nanotechnologies have been widely applied in diagnosis, therapeutic, and other biomedical areas. [7][8][9][10][11] On one hand, via the enhanced permeability and retention (EPR) effect, nanoparticles (NPs) accumulate at tumor sites, benefiting from the special environment of vascular malformation and lack of lymphatic circumfluence. On the other hand, hydrophobic drug molecules can be encapsulated in NPs with relatively high drug-loading efficiency and excellent stability.…”

Section: Introductionmentioning

confidence: 99%

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Zhang

Yang

et al. 2017

IJN

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Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic- co -glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed the stability, biocompatibility, passive targeting, and few side effects of RBCm-GA/PLGA nanoparticles. We expect to provide a new drug carrier in the treatment of colorectal cancer, which has strong clinical application prospects. In addition, the potential antitumor drug GA and other similar drugs could achieve broader clinical applications via this biomimetic nanocarrier.

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Engineered Multifunctional Nanocarriers for Cancer Diagnosis and Therapeutics

Cited by 97 publications

References 153 publications

Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects

Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects

Altering the response of intracellular reactive oxygen to magnetic nanoparticles using ultrasound and microbubbles

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

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