Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic‐Immune Combination Therapy for Colorectal Cancer
Lu‐Yi Ye,
Yi‐Shu Li,
Tong Ge
et al.
Abstract:Oncolytic virus therapy is currently regarded as a promising approach in cancer immunotherapy. It has greater therapeutic advantages for colorectal cancer that is prone to distant metastasis. However, the therapeutic efficacy and clinical application of viral agents alone for colorectal cancer remain suboptimal. In this study, we developed an engineered oncolytic vaccinia virus (OVV‐Luc) that expresses the firefly luciferase gene and loaded Chlorin e6 (Ce6) onto the virus surface through covalent coupling, res… Show more
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