Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function

Feiner, Ron; Engel, Leeya; Fleischer, Sharon; Malki, Maayan; Gal, Idan; Shapira, Assaf; Shacham‐Diamand, Yosi; Dvir, Tal

doi:10.1038/nmat4590

Cited by 381 publications

(347 citation statements)

References 44 publications

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“…For example, noradrenaline release near the cardiac layers may increase the contraction rate of the tissue. Recently our group has shown the ability to trigger the release of drugs by built-in layers of electronics (39). Integration of such a system as an additional layer within the engineered patch could provide on-demand spatiotemporal release of the different biofactors.…”

Section: Resultsmentioning

confidence: 99%

Modular assembly of thick multifunctional cardiac patches

Fleischer

Shapira

Feiner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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130

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In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distinct structures and functions. Albumin electrospun fiber scaffolds were laser-patterned to create microgrooves for engineering aligned cardiac tissues exhibiting anisotropic electrical signal propagation. Microchannels were patterned within the scaffolds and seeded with endothelial cells to form closed lumens. Moreover, cage-like structures were patterned within the scaffolds and accommodated poly(lactic-co-glycolic acid) (PLGA) microparticulate systems that controlled the release of VEGF, which promotes vascularization, or dexamethasone, an anti-inflammatory agent. The structure, morphology, and function of each layer were characterized, and the tissue layers were grown separately in their optimal conditions. Before transplantation the tissue and microparticulate layers were integrated by an ECM-based biological glue to form thick 3D cardiac patches. Finally, the patches were transplanted in rats, and their vascularization was assessed. Because of the simple modularity of this approach, we believe that it could be used in the future to assemble other multicellular, thick, 3D, functional tissues.

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Section: Resultsmentioning

confidence: 99%

Modular assembly of thick multifunctional cardiac patches

Fleischer

Shapira

Feiner

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

130

110

View full text Add to dashboard Cite

show abstract

“…Wireless sensing devices enable users to monitor and record their physiological data in real time [1][2][3] . Recently, artificial electronic skin (E-skin) that can simultaneously detect subtle pressure changes, the humidity, and the temperature has been intensively studied for its potential use in various applications, including health monitoring systems, medical diagnostics, soft robotics, and human-machine interfaces [4][5][6][7] . It has been demonstrated that flexible electronic devices and systems can be integrated with the human body or E-skin in the form of implantable, stick-on, or wearable electronics 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Wearable high-performance pressure sensors based on three-dimensional electrospun conductive nanofibers

2018

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Polymer-based pressure sensors play a key role in realizing lightweight and inexpensive wearable devices for healthcare and environmental monitoring systems. Here, conductive core/shell polymer nanofibers composed of poly (vinylidene fluoride-co-hexafluoropropene) (PVDF-HFP)/poly(3,4-ethylenedioxythiophene) (PEDOT) are fabricated using three-dimensional (3D) electrospinning and vapor deposition polymerization methods, and the resulting sponge-like 3D membranes are used to create piezoresistive-type pressure sensors. Interestingly, the PEDOT shell consists of well-dispersed spherical bumps, leading to the formation of a hierarchical conductive surface that enhances the sensitivity to external pressure. The sponge-like 3D mats exhibit a much higher pressure sensitivity than the conventional electrospun 2D mats due to their enhanced porosity and pressure-tunable contact area. Furthermore, large-area, wireless, 16 × 10 multiarray pressure sensors for the spatiotemporal mapping of multiple pressure points and wearable bands for monitoring blood pressure have been fabricated from these 3D mats. To the best of our knowledge, this is the first report of the fabrication of electrospun 3D membranes with nanoscopically engineered fibers that can detect changes in external pressure with high sensitivity. The developed method opens a new route to the mass production of polymer-based pressure sensors with high mechanical durability, which creates additional possibilities for the development of human-machine interfaces.

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“…25,26 Some recent nanotechnology progresses in the field have even added new levels of functionality beyond regeneration, such as status monitor and active control of implanted constructs, [27][28][29] as will be further discussed later in this review.…”

Section: Nanocomposite Bioinks For Te Strategiesmentioning

confidence: 99%

“…28,29,63 Independently of the final application, instrumented microphysiological devices, which are also known as organs-onchips, aim at real-time tracking and online monitoring and reporting of the engineered tissue performance without interfering with the signal reading on being implanted within the host.…”

Section: Integration Of Sensors In Te Systemsmentioning

confidence: 99%

Tissue Engineering and Regenerative Medicine: New Trends and Directions—A Year in Review

Gomes

Rodrigues

Domingues

et al. 2017

Tissue Engineering Part B: Reviews

147

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Tissue engineering (TE) is continuously evolving assimilating inputs from adjacent scientific areas and their technological advances, including nanotechnology developments that have been spawning the range of available options for the precise manipulation and control of cells and cellular environments. Simultaneously, with the maturation of the field, TE has a growing and marked impact in other fields, such as cancer and other diseases research, enabling tri-dimensional (3D) tumor/tissue models of increased complexity that more closely resemble living tissue dynamics, playing a decisive role in the development of new and improved therapies. Nevertheless, TE is still struggling with translational issues. On this matter, the advent of personalized and precision medicine has opened new perspectives, particularly with the striking evolutions enabled by 3D bioprinting technologies. Based on a modified methodology grounded in the past years' approach, we have identified and reviewed some of the most high-impact publications on the topics that are revolutionizing TE and helping to define the future directions of the field, namely: (1) New trends in TE: Personalized/precision regenerative medicine and 3D bioprinting, (2) Contributions of TE to other fields: microfabricated tissueengineered 3D models for cancer and other diseases research, and (3) Diagnostic and theranostic tools: monitoring and real-time control of TE systems.Keywords: 3D bioprinting, 3D disease models, nanotechnology, precision regenerative medicine, theranostic toolsThe Aim, Scope, and Methods of This Review S ince its origin, tissue engineering (TE) holds the promise of revolutionizing healthcare by providing artificially developed tissues and organs substitutes on demand. More recently, TE has expanded into different biomedical areas to feedback research and clinical needs, widening the range not only of possible successful therapies but also of diagnostic/screening tools. Considering the growing number of publications related with TE and approaching different scientific domains, such as cancer science or pharmaceutics research, the potential complementary role of the field in a multitude of clinical areas and therapies in the years to come is evident.Our review attempts to cover some of the most exciting research contributing to both regenerative medicine and in vitro research applications of engineered tissues, along with the novel technological approaches that are advancing the field. This is the fifth review of the kind in TE. The previous four articles [1][2][3][4] helped to establish the methodology adopted for selecting the areas of focus and the contributions to highlight. As in previous years, we started by searching the ISI Web of Knowledge database for articles in ''tissue engineering'' and ''regenerative medicine'' published during the period of September 2015 through December 2016, thus using a 3-month overlap with the previous review to not miss impactful articles in areas not addressed earlier.Similar to previous years, we also consid...

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Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function

Cited by 381 publications

References 44 publications

Modular assembly of thick multifunctional cardiac patches

Modular assembly of thick multifunctional cardiac patches

Wearable high-performance pressure sensors based on three-dimensional electrospun conductive nanofibers

Tissue Engineering and Regenerative Medicine: New Trends and Directions—A Year in Review

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