Engineered herbal scaffolds for tissue repair and regeneration: Recent trends and technologies

Agarwal, Tarun; Tan, Sheri-Ann; Onesto, Valentina; Law, Jia Xian; Agrawal, Garima; Pal, Sampriti; Lim, Wei Lee; Sharifi, Esmaeel; Moghaddam, Farnaz Dabbagh; Maiti, Tapas K.

doi:10.1016/j.bea.2021.100015

Cited by 39 publications

(23 citation statements)

References 166 publications

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“…The antibacterial activity of TMDC NZs, along with their relatively biocompatible nature, may be advantageous during the wound healing process. Bacterial infections have already been shown to delay healing by increasing inflammatory responses at the wound site [ 86 ]. As a result, using appropriate antibacterial agents could help to restore and balance the accurate healing microenvironment and avoid any delays.…”

Section: Tmdc Nanozymes: Application Perspectivementioning

confidence: 99%

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

et al. 2022

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Nanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a transition metal and X is a chalcogen element)-based nanozymes have demonstrated exceptional potential in the healthcare and diagnostic sectors. TMDCs have different enzymatic properties due to their unique nano-architecture, high surface area, and semiconducting properties with tunable band gaps. Furthermore, the compatibility of TMDCs with various chemical or physical modification strategies provide a simple and scalable way to engineer and control their enzymatic activity. Here, we discuss recent advances made with TMDC-based nanozymes for biosensing and therapeutic applications. We also discuss their synthesis strategies, various enzymatic properties, current challenges, and the outlook for future developments in this field.

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Section: Tmdc Nanozymes: Application Perspectivementioning

confidence: 99%

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

et al. 2022

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“…Natural substances have shown great potential for bone TE because of their many advantages, such as their cost‐effectiveness and lack of side effects 187 . Herbal extracts containing different types of phytochemicals (e.g., phenolic compounds, terpenes, phytohormones, and alkaloids) are attractive natural compounds that have achieved many investigations for healing purposes 186,188 . Some herbal extracts have been used in studies of stem cell proliferation and differentiation, including the aqueous extract of Alpinia oxyphllae , 163 the extract of Morinda citrifolia , which induces osteogenesis differentiation, 189,190 and the extract of Bacopa monnieri , which promotes neurogenesis 191 .…”

Section: Biochemical Factorsmentioning

confidence: 99%

“…In recent decades, the use of herbal extracts in scaffolds has advanced modern TE technologies due to their bioactive, nontoxic, nonimmunogenic, and cost‐effective properties, as well as their mechanical strength 186–188 . Therefore, herbal extracts have been used in approaches to promote tissue growth, to optimize bone and skin TE 187 .…”

Section: Biochemical Factorsmentioning

confidence: 99%

“…These naturally derived scaffolds also provide a robust system for drug delivery by combining the advantages of scaffolds and plant extracts, allowing controlled release of the drug, with less toxicity and side effects 187 . Some manufacturing technologies have been developed for drug delivery into biomaterials, such as freeze‐drying, solvent casting, 3D printing, electrospinning, and hydrogel formation, but there are still concerns about potential unsafe interactions at the implantation site and undesirable side effects 187,188 . Some potential herbal medicines for use in TE are listed in Table 3.…”

Section: Biochemical Factorsmentioning

confidence: 99%

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Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues

Bakhshandeh

Ranjbar

Abbasi

et al. 2022

Bioengineering & Transla Med

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Tissue engineering (TE) is currently considered a cutting-edge discipline that offers the potential for developing treatments for health conditions that negatively affect the quality of life. This interdisciplinary field typically involves the combination of cells, scaffolds, and appropriate induction factors for the regeneration and repair of damaged tissue. Cell fate decisions, such as survival, proliferation, or differentiation, critically depend on various biochemical and biophysical factors provided by the extracellular environment during developmental, physiological, and pathological processes. Therefore, understanding the mechanisms of action of these factors is critical to accurately mimic the complex architecture of the extracellular environment of living tissues and improve the efficiency of TE approaches. In this review, we recapitulate the effects that biochemical and biophysical induction factors have on various aspects of cell fate. While the role of biochemical factors, such as growth factors, small molecules, extracellular matrix (ECM) components, and cytokines, has been extensively studied in the context of TE applications, it is only recently that we have begun to understand the effects of biophysical signals such as surface topography, mechanical, and electrical signals. These biophysical cues could provide a more robust set of stimuli to manipulate cell signaling pathways during the formation of the engineered tissue.Furthermore, the simultaneous application of different types of signals appears to elicit synergistic responses that are likely to improve functional outcomes, which could help translate results into successful clinical therapies in the future.

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“…Stents implanted in the urethra are usually covered with antibacterial substances that do not directly support cell regeneration. At present, the trend in the selection of active substances supporting tissue regeneration is dominated by the use of mature resources in the form of herbs or plant extracts [ 49 , 50 , 51 ]. Among the natural substances supporting the regeneration and proper functioning of the genitourinary tract, there are mainly rye grass pollen (Secale cereale) , Serenoa repens , commonly known as saw palmetto, and African plum bark (Pygeum africanum) [ 52 , 53 , 54 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Mechanical Properties of Alginate-Gelatin Hydrogels with the Addition of Pygeum africanum with Potential Application in Urology

Kurowiak

Kaczmarek-Pawelska

Mackiewicz

et al. 2022

IJMS

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New hydrogel materials developed to improve soft tissue healing are an alternative for medical applications, such as tissue regeneration or enhancing the biotolerance effect in the tissue-implant–body fluid system. The biggest advantages of hydrogel materials are the presence of a large amount of water and a polymeric structure that corresponds to the extracellular matrix, which allows to create healing conditions similar to physiological ones. The present work deals with the change in mechanical properties of sodium alginate mixed with gelatin containing Pygeum africanum. The work primarily concentrates on the evaluation of the mechanical properties of the hydrogel materials produced by the sol–gel method. The antimicrobial activity of the hydrogels was investigated based on the population growth dynamics of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923, as well as the degree of degradation after contact with urine using an innovative method with a urine flow simulation stand. On the basis of mechanical tests, it was found that sodium alginate-based hydrogels with gelatin showed weaker mechanical properties than without the additive. In addition, gelatin accelerates the degradation process of the produced hydrogel materials. Antimicrobial studies have shown that the presence of African plum bark extract in the hydrogel enhances the inhibitory effect on Gram-positive and Gram-negative bacteria. The research topic was considered due to the increased demand from patients for medical devices to promote healing of urethral epithelial injuries in order to prevent the formation of urethral strictures.

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Engineered herbal scaffolds for tissue repair and regeneration: Recent trends and technologies

Cited by 39 publications

References 166 publications

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications

Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues

Changes in the Mechanical Properties of Alginate-Gelatin Hydrogels with the Addition of Pygeum africanum with Potential Application in Urology

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