Engineered Flt3L Drives Tolerogenic State to Attenuate Anti-drug Antibody Responses
Aaron T. Alpar,
Rachel P. Wallace,
Kirsten C. Refvik
et al.
Abstract:Immune reactions to protein drugs present substantial challenges to protein replacement for treating congenital diseases and metabolic deficiencies, due to the lack of endogenous tolerance or the protein drug's partial or total non-human origin. We sought to transiently modify the immune environment when the adaptive response to the drug antigen is mounted to lessen future reactions upon continued therapeutic treatment, without modifying the drug itself. Herein, we characterize a recombinant fusion of the cyto… Show more
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