Engineered exosomes for targeted delivery of miR-187-3p suppress the viability of hemangioma stem cells by targeting Notch signaling

Zhao, Ziqiang; Liu, Chao; Wang, Qizhang; Wu, Haiwei; Zheng, Jiawei

doi:10.21037/atm-21-4138

Cited by 4 publications

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After internalization, E-exos suppressed the Notch signaling pathway through the inhibition of miR-187-3p, thereby inhibiting the proliferation of HemSCs and providing a new research avenue for the treatment of IHs. 46 In the same year, based on the specific binding interaction between integrin α4β1 on the cell membrane of macrophages and vascular cell adhesion molecule-1 (VCAM-1), which is highly expressed on endothelial cells, 90 researchers co-incubated rapamycin with macrophage-derived exosomes and used extrusion to prepare drug-loaded particles (RNs). These particles were then encapsulated with PLGA microspheres to obtain rapamycin-encapsulated exosome-mimetic nanoparticles-in-PLGA microspheres (RNM).…”

Section: Targeting Strategy and Application Of Targeted Agents In Ihsmentioning

confidence: 99%

Recent Advances in Targeted Therapies for Infantile Hemangiomas

Liang,

Liu,

Tong

et al. 2024

IJN

View full text Add to dashboard Cite

Section: Targeting Strategy and Application Of Targeted Agents In Ihsmentioning

confidence: 99%

Recent Advances in Targeted Therapies for Infantile Hemangiomas

Liang,

Liu,

Tong

et al. 2024

IJN

View full text Add to dashboard Cite

Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

Liu,

Jin,

Chen

et al. 2023

Cell Commun Signal

View full text Add to dashboard Cite

Background Cells have been increasingly known to release extracellular vesicles (EVs) to the extracellular environment under physiological and pathological conditions. A plethora of studies have revealed that EVs contain cell-derived biomolecules and are found in circulation, thereby implicating them in molecular trafficking between cells. Furthermore, EVs have an effect on physiological function and disease development and serve as disease biomarkers. Main body Given the close association between EV circulation and vascular disease, this review aims to provide a brief introduction to EVs, with a specific focus on the EV cargoes participating in pathological mechanisms, diagnosis, engineering, and clinical potential, to highlight the emerging evidence suggesting promising targets in vascular diseases. Despite the expansion of research in this field, some noticeable limitations remain for clinical translational research. Conclusion This review makes a novel contribution to a summary of recent advances and a perspective on the future of EVs in vascular diseases.

show abstract

Research Progress on the Mechanism of Treatment of Infantile Hemangioma

孙

2024

ACM

View full text Add to dashboard Cite

Engineered exosomes for targeted delivery of miR-187-3p suppress the viability of hemangioma stem cells by targeting Notch signaling

Abstract: Contributions: (I) Conception and design: JW Zheng; (II) Administrative support: JW Zheng; (III) Provision of study materials or patients: ZL Zhao;

Cited by 4 publications

References 41 publications

Recent Advances in Targeted Therapies for Infantile Hemangiomas

Recent Advances in Targeted Therapies for Infantile Hemangiomas

Insight into extracellular vesicles in vascular diseases: intercellular communication role and clinical application potential

Research Progress on the Mechanism of Treatment of Infantile Hemangioma

Contact Info

Product

Resources

About