Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

Ma, Yilei; Yi, Jia; Ruan, Jing; Ma, Jiahui; Yang, Qinsi; Zhang, Kun; Zhang, Maolan; Zeng, Guoming; Jin, Libo; Huang, Xiaobei; Li, Jianshu; Yang, Haifeng; Wu, Wei; Sun, Da

doi:10.1002/adhm.202400514

Adv Healthcare Materials

2024

DOI: 10.1002/adhm.202400514

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Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

Yilei Ma,

Jia Yi,

Jing Ruan

et al.

Abstract: Gliomas, the most prevalent primary brain tumors, pose considerable challenges due to their heterogeneity, intricate tumor microenvironment (TME), and blood‐brain barrier (BBB), which restrict the effectiveness of traditional treatments like surgery and chemotherapy. This review provides an overview of engineered cell membrane technologies in glioma therapy, with a specific emphasis on targeted drug delivery and modulation of the immune microenvironment. This study investigates the progress in engineered cell … Show more

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Cited by 2 publications

References 157 publications

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Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

Yan,

Cao,

Yin

et al. 2024

Pharmaceutics

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Immunotherapy combats tumors by enhancing the body’s immune surveillance and clearance of tumor cells. Various nucleic acid drugs can be used in immunotherapy, such as DNA expressing cytokines, mRNA tumor vaccines, small interfering RNAs (siRNA) knocking down immunosuppressive molecules, and oligonucleotides that can be used as immune adjuvants. Nucleic acid drugs, which are prone to nuclease degradation in the circulation and find it difficult to enter the target cells, typically necessitate developing appropriate vectors for effective in vivo delivery. Biomimetic drug delivery systems, derived from viruses, bacteria, and cells, can protect the cargos from degradation and clearance, and deliver them to the target cells to ensure safety. Moreover, they can activate the immune system through their endogenous activities and active components, thereby improving the efficacy of antitumor immunotherapeutic nucleic acid drugs. In this review, biomimetic nucleic acid delivery systems for relieving a tumor immunosuppressive microenvironment are introduced. Their immune activation mechanisms, including upregulating the proinflammatory cytokines, serving as tumor vaccines, inhibiting immune checkpoints, and modulating intratumoral immune cells, are elaborated. The advantages and disadvantages, as well as possible directions for their clinical translation, are summarized at last.

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Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

Yan,

Cao,

Yin

et al. 2024

Pharmaceutics

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Cell Membrane-Coated Nanoparticles for Dental, Oral, and Craniofacial Diseases

Wang,

Li,

Zhou

et al. 2024

Research

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Dental, oral, and craniofacial diseases can substantially impact the quality of human life, thereby posing a serious public health concern. Although conventional therapies such as surgery have solved these problems largely, the prognosis of patients is not always satisfactory. Cell membrane-coated nanoparticles (CMCNPs) carry nanodrugs with the help of natural cell membranes, therefore utilizing their remarkable ability to interface and interact with their surrounding environment. These nanoparticles have demonstrated substantial advantages in drug targeting, prolonging blood circulation time, penetrating biofilms, and immune escape. With the assistance of CMCNPs, the therapeutic effects of dental, oral, and craniofacial diseases can reach a higher level. CMCNPs have been applied for dental, oral, and craniofacial diseases for various conditions such as head and neck cancer, periodontal disease, and oral biosignal detection. For the therapies of head and neck cancer, CMCNPs have been widely utilized as a tool of chemotherapy, phototherapy, and immunotherapy, while yet to be exploited in imaging technique. In the end, we summarized the challenges and prospectives of CMCNPs for dental, oral, and craniofacial diseases: large-scale production with uniform standards and high quantity, extensive application directions in dental, oral, and craniofacial regions (implant, endodontics), and the promotion of its clinical application.

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Engineered Cell Membrane‐Coated Nanoparticles: New Strategies in Glioma Targeted Therapy and Immune Modulation

Cited by 2 publications

References 157 publications

Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

Cell Membrane-Coated Nanoparticles for Dental, Oral, and Craniofacial Diseases

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