Engineered cell-laden thermosensitive poly(N-isopropylacrylamide)-immobilized gelatin microspheres as 3D cell carriers for regenerative medicine

Yang, I‐Hsuan; Kuan, Che‐Yung; Chen, Zhiyu; Li, Chi-Han; Chi, Chih-Ying; Lin, Yu Ying; Liang, Ya‐Jyun; Kuo, Wei‐Ting; Li, Yi-An; Lin, Feng-Huei

doi:10.1016/j.mtbio.2022.100266

Cited by 8 publications

(4 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another cause widely related to shifting of this peak can results from the interaction between the dispersed particles, and the gelatin chains, which was not observed neither. This agrees with the stability tests in Figure 7, and follows the same trend as previous work by Fernandes et al 64 for gelatin-sepiolite composites. In another study 65 , gelatin composite was prepared with magnetite nanoparticles, leading to a 6 °C increase of melting temperature of gelatin, attributed to an increase in crosslink density by the nanoparticles.…”

Section: Efficiency Of Compositessupporting

confidence: 93%

Synthesis and Characterization of Carboxylic- and Amine-Grafted Fau Zeolites as Inorganic Fillers to Design Biocompatible Composites

Menard,

Zarbaliyev,

Echalard

et al. 2023

Preprint

View full text Add to dashboard Cite

Section: Efficiency Of Compositessupporting

confidence: 93%

Synthesis and Characterization of Carboxylic- and Amine-Grafted Fau Zeolites as Inorganic Fillers to Design Biocompatible Composites

Menard,

Zarbaliyev,

Echalard

et al. 2023

Preprint

View full text Add to dashboard Cite

“…For example, in cardiac tissue engineering, cell-laden scaffolds can mimic the contractile behavior of the heart by altering their mechanical properties in response to electrical signals. This adaptability promotes the maturation of cardiac cells and improves the functional integration of the regenerated tissue [90].…”

Section: Cell-laden Materials Applicationsmentioning

confidence: 99%

From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine

Kantaros,

Ganetsos

2023

IJMS

View full text Add to dashboard Cite

The emerging field of regenerative medicine holds immense promise for addressing complex tissue and organ regeneration challenges. Central to its advancement is the evolution of additive manufacturing techniques, which have transcended static constructs to embrace dynamic, biomimetic solutions. This manuscript explores the pivotal role of smart materials in this transformative journey, where materials are endowed with dynamic responsiveness to biological cues and environmental changes. By delving into the innovative integration of smart materials, such as shape memory polymers and stimulus-responsive hydrogels, into additive manufacturing processes, this research illuminates the potential to engineer tissue constructs with unparalleled biomimicry. From dynamically adapting scaffolds that mimic the mechanical behavior of native tissues to drug delivery systems that respond to physiological cues, the convergence of smart materials and additive manufacturing heralds a new era in regenerative medicine. This manuscript presents an insightful overview of recent advancements, challenges, and future prospects, underscoring the pivotal role of smart materials as pioneers in shaping the dynamic landscape of regenerative medicine and heralding a future where tissue engineering is propelled beyond static constructs towards biomimetic, responsive, and regenerative solutions.

show abstract

“…Stem cell transplantation in myocardial repair [137] Sodium alginate-g-poly (N-isopropylacrylamide) Curcumin Wound healing [24] poly(Nisopropylacrylamide) Wharton s jelly-derived mesenchymal stem cells 3D cell carriers for regenerative medicine [138] poly(Nisopropylacrylamide) Dextran Postinfarct heart failure After degradation [139]…”

Section: Brown Adipose-derived Stem Cellsmentioning

confidence: 99%

Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy

et al. 2022

View full text Add to dashboard Cite

Thermosensitive hydrogels, having unique sol–gel transition properties, have recently received special research attention. These hydrogels exhibit a phase transition near body temperature. This feature is the key to their applications in human medicine. In addition, hydrogels can quickly gel at the application site with simple temperature stimulation and without additional organic solvents, cross-linking agents, or external equipment, and the loaded drugs can be retained locally to improve the local drug concentration and avoid unexpected toxicity or side effects caused by systemic administration. All of these features have led to thermosensitive hydrogels being some of the most promising and practical drug delivery systems. In this paper, we review thermosensitive hydrogel materials with biomedical application potential, including natural and synthetic materials. We describe their structural characteristics and gelation mechanism and briefly summarize the mechanism of drug release from thermosensitive hydrogels. Our focus in this review was to summarize the application of thermosensitive hydrogels in disease treatment, including the postoperative recurrence of tumors, the delivery of vaccines, the prevention of postoperative adhesions, the treatment of nervous system diseases via nasal brain targeting, wound healing, and osteoarthritis treatment.

show abstract

Engineered cell-laden thermosensitive poly(N-isopropylacrylamide)-immobilized gelatin microspheres as 3D cell carriers for regenerative medicine

Cited by 8 publications

References 58 publications

Synthesis and Characterization of Carboxylic- and Amine-Grafted Fau Zeolites as Inorganic Fillers to Design Biocompatible Composites

Synthesis and Characterization of Carboxylic- and Amine-Grafted Fau Zeolites as Inorganic Fillers to Design Biocompatible Composites

From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine

Thermosensitive Hydrogels and Advances in Their Application in Disease Therapy

Contact Info

Product

Resources

About