Engineered cell-based therapies in ex vivo ready-made CellDex capsules have therapeutic efficacy in solid tumors

Schaik, Thijs A. van; Moreno-Lama, Lucia; Farzani, Touraj Aligholipour; Wang, Mian; Chen, Kok‐Siong; Li, Wanlu; Cai, Ling; Zhang, Yu Shrike; Shah, Khalid

doi:10.1016/j.biopha.2023.114665

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“…This shielding method enables controllable virus release, and localized gene expression in the surrounding environment after local administration. 14 , 15 However, this treatment is mainly suitable for local delivery and has restricted application, necessitating the exploration of more ideal OV delivery systems. This review concentrates on the research concerning nanoparticles (NPs) and cells as delivery carriers.…”

Section: Introductionmentioning

confidence: 99%