Engineered CD147-CAR macrophages for enhanced phagocytosis of cancers
Koollawat Chupradit,
Saitong Muneekaew,
Methichit Wattanapanitch
Abstract:Chimeric antigen receptor (CAR) T cell therapy has shown promising results in hematologic malignancies, but its effectiveness in solid cancers remains challenging. Macrophages are immune cells residing within the tumor microenvironment. They can phagocytose tumor cells. Recently, CAR macrophages (CAR-M) have been a promising candidate for treating solid cancers. One of the common cancer antigens overexpressed in various types of cancer is CD147. CAR-T and NK cells targeting CD147 antigen have shown significant… Show more
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