Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics

Guo, Yunqi; Wang, Zhiqiang; Shen, Mingwu

doi:10.1002/exp.20210171

Cited by 58 publications

(29 citation statements)

References 74 publications

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“…In addition, MMPs can be directly visualized and targeted in lung cancer tissue with the use of nanotheranostic platforms conjugated with peptides degradable by these enzymes [ 10 ]. Moreover, nanoprobes containing MMPs' detection systems can be coated with cell membranes, for instance, red blood cell membranes or cancer cell membranes (CCMs), to avoid the clearance of nanocarriers by the reticuloendothelial system (RES) [ 41 ]. Additionally, the fusion of CCMs with other types of cell membranes (engineered CCMs [ECCMs]) takes advantage of their characteristics, allowing its use for theranostic purposes.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinases and Stress Hormones in Lung Cancer Progression

González-Ávila

Sommer

García-Hernández

et al. 2022

Journal of Oncology

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Several matrix metalloproteinases (MMPs) and psychological stress are associated with poor cancer prognosis. The current work goal was to determine MMPs’ and stress hormones’ blood concentrations from lung adenocarcinoma (LAC) patients. Patients were divided into the following groups: tobacco smokers (TS), wood smoke-exposed (W), passive smokers (PS), TS exposed to wood smoke (TW), and patients with no recognizable risk factor (N). MMPs, tissue inhibitors of metalloproteinases (TIMPs), adrenaline, noradrenaline, and cortisol blood concentrations were measured by ELISA. Zymography and Western blot assays were performed to determine MMP-2 and MMP-9 active and latent forms. MMP-2, MMP-3, MMP-9, and TIMP-1 blood concentrations, and MMP-9 gelatinase activity were augmented, while MMP-12, MMP-14, and TIMP-2 were diminished in LAC patients. Cortisol was increased in LAC samples. Adrenaline concentrations were higher in W, TS, and TW, and noradrenaline was increased in W and N groups. Positive correlations were observed among cortisol and TIMP-1 ( r s = 0.392 ) and TIMP-2 ( r s = 0.409 ) in the W group and between noradrenaline and MMP-2 ( r s = 0.391 ) in the N group. MMPs’ blood concentration increments can be considered as lung cancer progression markers. Although stress hormones were also augmented, only weak correlations were observed between them and MMPs and TIMPs.

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Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinases and Stress Hormones in Lung Cancer Progression

González-Ávila

Sommer

García-Hernández

et al. 2022

Journal of Oncology

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“…To date, biomimetic membrane encapsulation approaches containing erythrocyte membrane-based, platelet membrane-based, cancer cell membrane-based, macrophage membrane-based and stem cell membrane-based biomimetic drug delivery systems are highlighted because of their diverse characteristics. [108] Furthermore, membrane encapsulation as a typical biomimetic strategy instead of traditional chemical modified methods avoids the cumbersome retouching process of nanodrug and endows it with favorable biological functions, heightening the antitumor effect. [109] The existence of transmembrane protein CD47 expressing on the erythrocyte membrane is beneficial for nanoparticles to avoid phagocytosis by macrophage, thus realizing long-term in vivo circulation of nanoparticles.…”

Section: Biomimetic Drug Deliverymentioning

confidence: 99%

Nanobiomimetic Medicine

Chang

Dong

Huang

et al. 2022

Adv Funct Materials

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The application of nanotechnology in medicine aims at developing the precise theranostics of diseases by leveraging the extraordinary effects of engineered nanomedicines, materdicine, and biomaterials. However, finely controlling the biological behavior of nanomaterials in the complex living systems remains a great challenge in terms of accuracy and intelligence. Inspired by nature, biomimetics has become an attractive strategy based on the highly ordered natural biological structure for the development of clinically valuable materials and technologies, arising from the superior bioavailability. The rapid development of biomimetics in nanomedical applications prompts the authors to propose the concept of “nanobiomimetic medicine”, which is a considerable subdiscipline in nanomedicine and materdicine that applies the concept and strategies of biomimetics to facilitate and promote the disease theranostics. Herein, the authors aim to furnish a state‐of‐the‐art review on the latest progress in the field of nanobiomimetic medicine. The design strategies, structural features and biological properties of biomimetic materials are initially introduced to reveal the inherent bionic mechanism and the potential structure‐function relationships. Furthermore, advances with respect to the applications of diverse biomimetic materials are comprehensively summarized. Finally, the current challenges and future direction of nanobiomimetic medicine are discussed and prospected in order to stimulate more biomimetic fundamental and technological breakthroughs in nanomedicine.

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“…Bioinspiration and biomimicry technologies can not only simulate biological materials by their chemical structure but also by their biological functions. By mimicking the cell membranes, biomimetic nanomaterials can delay the clearance of MPS and increase circulation time ( Guo et al, 2022 ). Leukocytes are one of the most crucial immune components of the immune system.…”

Section: Nanomaterials-mediated Therapeutics Strategies For MImentioning

confidence: 99%

Nanomaterials-Mediated Therapeutics and Diagnosis Strategies for Myocardial Infarction

et al. 2022

Front. Chem.

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The alarming mortality and morbidity rate of myocardial infarction (MI) is becoming an important impetus in the development of early diagnosis and appropriate therapeutic approaches, which are critical for saving patients’ lives and improving post-infarction prognosis. Despite several advances that have been made in the treatment of MI, current strategies are still far from satisfactory. Nanomaterials devote considerable contribution to tackling the drawbacks of conventional therapy of MI by improving the homeostasis in the cardiac microenvironment via targeting, immune modulation, and repairment. This review emphasizes the strategies of nanomaterials-based MI treatment, including cardiac targeting drug delivery, immune-modulation strategy, antioxidants and antiapoptosis strategy, nanomaterials-mediated stem cell therapy, and cardiac tissue engineering. Furthermore, nanomaterials-based diagnosis strategies for MI was presented in term of nanomaterials-based immunoassay and nano-enhanced cardiac imaging. Taken together, although nanomaterials-based strategies for the therapeutics and diagnosis of MI are both promising and challenging, such a strategy still explores the immense potential in the development of the next generation of MI treatment.

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Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics

Cited by 58 publications

References 74 publications

Matrix Metalloproteinases and Stress Hormones in Lung Cancer Progression

Matrix Metalloproteinases and Stress Hormones in Lung Cancer Progression

Nanobiomimetic Medicine

Nanomaterials-Mediated Therapeutics and Diagnosis Strategies for Myocardial Infarction

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