Engineered beads-on-a-string nanocomposites for an improved drug fast-sustained bi-stage release

Gong, Wenjian; Yang, Wei; Zhou, Jianfeng; Zhang, Shuping; Yu, Deng-Guang; Liu, Ping

doi:10.1080/20550324.2024.2362477

Cited by 9 publications

(3 citation statements)

References 81 publications

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“…24,25 Not only for quercetin, the administration of low-soluble drugs is one of the main complications in pharmaceutics. 26 Nanofibers are employed as a viable tool to enhance the solubility of drugs by co-dissolving them with polymers. 27 However, it is challenging to enhance the solubility of some poorly water-soluble drugs due to the lack of suitable solvents, resulting in their diminished activity.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

Alishahi,

Xiao,

Kreismanis

et al. 2024

ACS Appl. Bio Mater.

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Quercetin, recognized for its antioxidant, antiinflammatory, and antibacterial properties, faces limited biomedical application due to its low solubility. Cotton, a preferred wound dressing material over synthetic ones, lacks inherent antibacterial and wound-healing attributes and can benefit from quercetin features. This study explores the potential of overcoming these challenges through the inclusion complexation of quercetin with cyclodextrins (CDs) and the development of a nanofibrous coating on a cotton nonwoven textile. Hydroxypropyl-beta-cyclodextrin (HP-β-CD) and hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) formed inclusion complexes of quercetin, with chitosan added to enhance antibacterial properties. Phase solubility results showed that inclusion complexation can enhance quercetin solubility up to 20 times, with HP-γ-CD forming a more stable inclusion complexation compared with HP-β-CD. Electrospinning of the nanofibers from HP-β-CD/Quercetin and HP-γ-CD/Quercetin aqueous solutions without the use of a polymeric matrix yielded a uniform, smooth fiber morphology. The structural and thermal analyses of the HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers confirmed the presence of inclusion complexes between quercetin and each of the CDs (HP-β-CD and HP-γ-CD). Moreover, HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers showed a near-complete loading efficiency of quercetin and followed a fastreleasing profile of quercetin. Both HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers showed significantly higher antioxidant activity compared to pristine quercetin. The HP-β-CD/Quercetin and HP-γ-CD/Quercetin nanofibers also showed antibacterial activity, and with the addition of chitosan in the HP-γ-CD/Quercetin system, the Chitosan/HP-γ-CD/Quercetin nanofibers completely eliminated the investigated bacteria species. The nanofibers were nontoxic and well-tolerated by cells, and exploiting the quercetin and chitosan anti-inflammatory activities resulted in the downregulation of IL-6 and NO secretion in both immune as well as regenerative cells. Overall, CD inclusion complexation markedly enhances quercetin solubility, resulting in a biofunctional antioxidant, antibacterial, and anti-inflammatory wound dressing through a nanofibrous coating on cotton textiles.

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Section: Introductionmentioning

confidence: 99%

“…Not only for quercetin, the administration of low-soluble drugs is one of the main complications in pharmaceutics . Nanofibers are employed as a viable tool to enhance the solubility of drugs by co-dissolving them with polymers .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

Alishahi,

Xiao,

Kreismanis

et al. 2024

ACS Appl. Bio Mater.

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“…22 Prolonged release formulations of ropinirole using 3D printing techniques offer a promising solution to these challenges. It should be noted, that the controlled release of drug substances is important not only for DDS, 23,24 but also for a wide variety of medical devices. 25,26 Integration of manufacturing techniques is highly desired for developing novel functional materials.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Drug Delivery Systems in Action–Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena

Baran,

Birczyński,

Milanowski

et al. 2024

ACS Appl. Mater. Interfaces

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The hypothesis of the study was that (1) 3D printed drug delivery systems (DDS) could be characterized in situ during drug release using NMR/MRI techniques in terms of mass transport phenomena description (interfacial phenomena), particularly for systems dealing with two mobile phases (e.g., water and low molecular weight liquid polymer); (2) consequently, it could be possible to deduce how these interfacial mass transport phenomena influence functional properties of 3D printed DDS. Matrix drug delivery systems, prepared using masked stereolithography (MSLA), containing poly(ethylene glycol) diacrylate (PEGDA) and low molecular weight polyethylene glycol (PEG) with ropinirole hydrochloride (RH) were studied as example formulations. The PEGDA to PEG (mobile phase) concentration ratio influenced drug release. It was reflected in spatiotemporal changes in parametric T 2 relaxation time (T 2 ) and amplitude (A) images obtained using magnetic resonance imaging (MRI) and T 1 -T 2 relaxation time correlations obtained using low-field time-domain nuclear magnetic resonance (LF TD NMR) relaxometry during incubation in water. For most of the tested formulations, two signal components related to PEG and water were assessed in the hydrated matrices by MRI relaxometry (parametric T 2 /A images). The PEG component faded out due to outward PEG diffusion and was gradually replaced by the water component. Both components spatially and temporally changed their parameters, reflecting evolving water−polymer interactions.The study shows that dynamic phenomena related to bidirectional mass transport can be quantified in situ using NMR and MRI techniques to gain insight into drug release mechanisms from 3D printed DDS systems.

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Hybrid Polyvinyl Alcohol-Silica Antibacterial Nanofiber Fabricated by Combined Sol-Gel and Electrospinning Techniques

El Kalaaoui,

Boukhriss,

Bili

et al. 2024

J Sol-Gel Sci Technol

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Engineered beads-on-a-string nanocomposites for an improved drug fast-sustained bi-stage release

Cited by 9 publications

References 81 publications

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin–Quercetin Inclusion Complex Nanofibers

3D Printed Drug Delivery Systems in Action–Magnetic Resonance Imaging and Relaxometry for Monitoring Mass Transport Phenomena

Hybrid Polyvinyl Alcohol-Silica Antibacterial Nanofiber Fabricated by Combined Sol-Gel and Electrospinning Techniques

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