Engineered Antibodies to Improve Efficacy against Neurodegenerative Disorders
Sarfaraz K. Niazi,
Zamara Mariam,
Matthias Magoola
Abstract:Antibodies that can selectively remove rogue proteins in the brain are an obvious choice to treat neurodegenerative disorders (NDs), but after decades of efforts, only two antibodies to treat Alzheimer’s disease are approved, dozens are in the testing phase, and one was withdrawn, and the other halted, likely due to efficacy issues. However, these outcomes should have been evident since these antibodies cannot enter the brain sufficiently due to the blood–brain barrier (BBB) protectant. However, all products c… Show more
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