Engine shutdown: migrastatic strategies and prevention of metastases

MACC1-induced migration in tumors: Current state and perspective

“…Currently, several drugs are under clinical trials which have at least a partial inhibitory effect on cell migration, potentially affecting metastasis formation ( 234 ). Given the clear association between MACC1 and poor survival and increased metastasis in so many tumor entities and its tight relation to cell migration and the cytoskeletal or adhesive system, it is likely that targeting MACC1 and analyzing its signal cascades will help to better understand the metastatic processes and develop precise tools to interact with tumor progression.…”

“…Inhibiting cancer cell migration and thus ultimately metastasis formation is one approach to fight against cancer. Yet, many clinical trials targeting migration-associated molecules had only limited success, if at all ( 233 , 234 ). The MACC1-dependent signaling network could be an additional piece to the puzzle helping to bridge the gap between preclinical research and the successful clinical application of anti-migratory drugs.…”

Dielectrophoretic enrichment of live chemo-resistant circulating-like pancreatic cancer cells from media of drug-treated adherent cultures of solid tumors

“…An overwhelming majority of cancer fatalities are attributed to metastasis, 1,2 motivating the interest in developing therapeutics that target this mechanism. 3 This need is especially critical for pancreatic cancer arising from pancreatic ductal adenocarcinoma (PDAC), which is the third leading cause of cancer deaths 4 and has the shortest survival duration, due to its propensity for tumor metastasis. [5][6][7] However, due to intra-tumoral heterogeneity, only a subpopulation of the parent cancer cells exhibits the ability for metastasis.…”

Therapeutic potential and limitations of curcumin as antimetastatic agent

“…Nevertheless, CTC clusters display metastatic potential of 20-to 100-fold greater metastatic potential than single CTCs [12][13][14]. Other possible targets of migrastatic agents are mechanisms of cell mobility (e.g., cytoskeletal dynamics and cell contractility) and energy provisions (e.g., ATP availability, mitochondrial metabolism) [15].…”