Engagement of the medical-technology sector with society

Williams, David; Edelman, Elazer R.; Radišić, Milica; Laurencin, Cato T.; Untereker, Darrel F.

doi:10.1126/scitranslmed.aal4359

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…Optogenetic techniques utilizing light-sensitive optogenetic actuators such as channelrhodopsin, halorhodopsin, and archaerhodopsin selectively control and record the activities of neurons by applying light to a neuron bundle and precisely control the target sites and time compared with electrical stimulations. [100][101][102] In the early days of optogenetics, research was conducted to activate neurons in the brain, but recently its applications have been extended to the heart, bladder, and other tissues as well as the brain. [103][104][105] Representatively, Mickle et al used resistive strain sensors to monitor bladder functions in real time and adopted optogenetic techniques for peripheral neuromodulation in the bladder via μLED.…”

Section: Smart Sensing Systems Applied With Phototherapymentioning

confidence: 99%

Smart Sensing Systems Using Wearable Optoelectronics

Hwang

et al. 2020

Advanced Intelligent Systems

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A wearable smart sensing system is capable of continuously monitoring biometric information such as respiration, pulse, and body temperature while attached to an arbitrary surface on the user's body to be utilized freely during activities. Research conducted on new materials, fabrication processes, structure of electrodes, and wireless communication technologies has made constant progress in the development of smart sensing systems that use entirely wearable forms of devices to go beyond conventional devices that are based on intrinsically rigid components, such as silicon. Among various platforms that can be used in the development of smart sensing systems, optoelectronics provides innovative sensing functions (e.g., human–machine interfaces and phototherapy) that can be transferred from traditional healthcare to smart healthcare, such as point of care. Optoelectronics are light‐mediated displays that allow a light source to be controlled and a large light spectrum to be detected. Recently, this platform that uses smart and wearable optoelectronic sensing systems has become increasingly advanced to better help human beings treat their diseases through self‐healthcare. Herein, recent advanced technologies in materials, structures, and wireless platforms for smart sensors using wearable optoelectronics are reviewed.

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Section: Smart Sensing Systems Applied With Phototherapymentioning

confidence: 99%

Smart Sensing Systems Using Wearable Optoelectronics

Hwang

et al. 2020

Advanced Intelligent Systems

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“…De hecho, la noción de Medicina Traslacional implica que la investigación biomédica es un proceso continuo que parte desde la investigación básica, hasta su implementación y evaluación de impacto en la salud de las personas en contextos de práctica cotidiana (40). De tal modo que la implementación debe su pertinencia a ciertos momentos específicos de la investigación.…”

Section: Estudios Híbridos De Implementación Y Efectividadunclassified

Ciencias de la implementación: de la evidencia a la práctica

2017

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La amplia gama de evidencias científicas que respaldan diversas intervenciones clínicas no son suficientes para que dichas intervenciones se utilicen en la práctica. De tal modo que la Medicina Basada en la Evidencia debe dar el paso hacia la Practica Basada en la Evidencia, a través de procesos de implementación que permitan desplegar y contextualizar intervenciones en salud respaldadas por la evidencia. Para tal fin se ha desarrollado la Ciencia de la implementación, la cual investiga los factores que influencian el uso efectivo y completo de las innovaciones científicas en la práctica, intentando maximizar los beneficios de las intervenciones en salud. Esta ciencia se define como el estudio de los métodos que promueven la incorporación sistemática de hallazgos de investigación en la rutina clínica, con el objetivo de mejorar la calidad y efectividad de los servicios e intervenciones en salud. El propósito de este artículo es introducir el concepto de Ciencia de la Implementación en relación con la epidemiología clínica y establecer las razones por las cuales existe una imperiosa necesidad de su desarrollo. Además, tiene el propósito de explicar el porqué de la necesidad de acelerar la aplicación efectiva de la Medicina Basada en Evidencia y definir los principales modelos que precisan el ámbito de trabajo de esta ciencia, incluyendo: las particularidades de los estudios de implementación, sus diferencias con los estudios clásicos de la epidemiología clínica, los modelos de implementación y evaluación, así como la definición de los desenlaces esperados en un estudio de implementación.

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“…[10][11][12] In consideration of ethical issues, the process of gene engineering and transfection into human cells may also depress the potential use of optogenetics in related researches. [13,14] Photodamage to cells has long been noted and studied. The complex cell response implies laser irradiation can induce tremendous molecular changes in cells.…”

Section: Introductionmentioning

confidence: 99%

Photoactivation of Extracellular‐Signal‐Regulated Kinase Signaling in Target Cells by Femtosecond Laser

Wang

Liu

Zhang

et al. 2018

Laser & Photonics Reviews

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Optogenetics employs light to manipulate cellular events such as activation of molecular channels, signaling molecules, and gene transcription, by transfection with engineered light‐sensitive proteins. In the last decade, great progresses in life science have been made by optogenetics, but the gene transfection limits its further medical applications. In this study, it is reported that a short flash of femtosecond‐laser stimulation can directly activate extracellular signal‐regulated kinase (ERK), an essential signaling pathway, in target cells, without any optogenetic technology. This all‐optical approach can be easily accomplished by a two‐photon or confocal microscope coupled with a femtosecond laser. The photostimulation can initiate immediate ERK translocation into nucleus and exit back to cytosol. The nuclear ERK level can be regulated by combination of multiple photostimulations. Subsequent up‐regulation of phosphorylated endogenous eIF4E indicates successful activation of the ERK signaling pathway. Occasionally, ERK activation in the surrounding cells of the stimulation is observed. Some key signaling cascades in the ERK2 pathway activated by photostimulation is further clarified. Altogether, this all‐optical method can activate ERK without any exogenous chemicals or proteins and thus be with promissing potential for related research.

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Engagement of the medical-technology sector with society

Cited by 6 publications

References 8 publications

Smart Sensing Systems Using Wearable Optoelectronics

Smart Sensing Systems Using Wearable Optoelectronics

Ciencias de la implementación: de la evidencia a la práctica

Photoactivation of Extracellular‐Signal‐Regulated Kinase Signaling in Target Cells by Femtosecond Laser

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