Engagement of Language and Domain General Networks during Word Monitoring in a Native and Unknown Language

Cotosck, Kelly R.; Meltzer, Jed A.; Nucci, Mariana Penteado; Lukášová, Kateřina; Amaro, Edson

doi:10.3390/brainsci11081063

Cited by 8 publications

(6 citation statements)

References 52 publications

(66 reference statements)

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“…This might be the result of listening to recordings in a language one does not comprehend in the context of a language you understand very well within the same run. A similar native vs unknown language comprehension effect has been found in prior work (Cotosck et al, 2021) using a target word detection task whilst listening to stories. On the other hand, language-specific acoustic differences (Mennen et al, 2012, see also Supplementary S4.2) might have driven some of these differences, particularly in the TVA.…”

Section: Resultssupporting

confidence: 81%

Auditory dyadic interactions through the ‘eye’ of the social brain: How visual is the posterior STS interaction region?

Landsiedel

Koldewyn

2023

Preprint

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Human interactions contain potent social cues that not only meet the eye but also the ear. Although research has identified a region in the posterior superior temporal sulcus as being particularly sensitive to visually presented social interactions (SI-pSTS), its response to auditory interactions has not been tested. Here, we used fMRI to explore brain response to auditory interactions, with a focus on temporal regions known to be important in auditory processing and social interaction perception. In Experiment 1, monolingual participants listened to two-speaker conversations (intact or sentence-scrambled) and one-speaker narrations in both a known and unknown language. Speaker number and conversational coherence were explored in separately localised regions-of-interest (ROI). In Experiment 2, bilingual participants were scanned to explore the role of language comprehension. Combining univariate and multivariate analyses, we found initial evidence for a heteromodal response to social interactions in SI-pSTS. Specifically, right SI-pSTS preferred auditory interactions over control stimuli and represented information about both speaker number and interactive coherence. Bilateral temporal voice areas (TVA) showed a similar, but less specific, profile. Exploratory analyses identified another auditory-interaction sensitive area in anterior STS. Indeed, direct comparison suggests modality specific tuning, with SI-pSTS preferring visual information while aSTS prefers auditory information. Altogether, these results suggest that right SI-pSTS is a heteromodal region that represents information about social interactions in both visual and auditory domains. Future work is needed to clarify the roles of TVA and aSTS in auditory interaction perception and further probe right SI-pSTS interaction-selectivity using non-semantic prosodic cues.

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Section: Resultssupporting

confidence: 81%

Auditory dyadic interactions through the ‘eye’ of the social brain: How visual is the posterior STS interaction region?

Landsiedel

Koldewyn

2023

Preprint

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“…By contrast, the groups of patients with ADHD showed a higher correlation between VMHC and handedness across several networks (Basal Ganglia, Language, ventral DMN, Visuospatial Networks). These findings show similar patterns to the high inter-participant and task-specific variability of lateralization in language processing areas (Cotosck et al, 2021 ; Gurunandan et al, 2020 ; Olulade et al, 2020 ; Vigneau et al, 2011 ), where marked functional lateralization is not clearly correlated to better performance. In turn, ventral DMN is central not only for sustained-attention (Sormaz et al, 2018 ) or goal-oriented behavior (Murphy et al, 2018 ; Spreng, 2012 ), but also for semantic fluency, entailing both cognition and memory (Martin et al, 2021 ).…”

Section: Discussionsupporting

confidence: 80%

Centrality and interhemispheric coordination are related to different clinical/behavioral factors in attention deficit/hyperactivity disorder: a resting-state fMRI study

Tarchi

Damiani

Fantoni

et al. 2022

Brain Imaging and Behavior

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Eigenvector-Centrality (EC) has shown promising results in the field of Psychiatry, with early results also pertaining to ADHD. Parallel efforts have focused on the description of aberrant interhemispheric coordination in ADHD, as measured by Voxel-Mirrored-Homotopic-Connectivity (VMHC), with early evidence of altered Resting-State fMRI. A sample was collected from the ADHD200-NYU initiative: 86 neurotypicals and 89 participants with ADHD between 7 and 18 years old were included after quality control for motion. After preprocessing, voxel-wise EC and VMHC values between diagnostic groups were compared, and network-level values from 15 functional networks extracted. Age, ADHD severity (Connor’s Parent Rating-Scale), IQ (Wechsler-Abbreviated-Scale), and right-hand dominance were correlated with EC/VMHC values in the whole sample and within groups, both at the voxel-wise and network-level. Motion was controlled by censoring time-points with Framewise-Displacement > 0.5 mm, as well as controlling for group differences in mean Framewise-Displacement values. EC was significantly higher in ADHD compared to neurotypicals in the left inferior Frontal lobe, Lingual gyri, Peri-Calcarine cortex, superior and middle Occipital lobes, right inferior Occipital lobe, right middle Temporal gyrus, Fusiform gyri, bilateral Cuneus, right Precuneus, and Cerebellum (FDR-corrected-p = 0.05). No differences were observed between groups in voxel-wise VMHC. EC was positively correlated with ADHD severity scores at the network level (at p-value < 0.01, Inattentive: Cerebellum rho = 0.273; Hyper/Impulsive: High-Visual Network rho = 0.242, Cerebellum rho = 0.273; Global Index Severity: High-Visual Network rho = 0.241, Cerebellum rho = 0.293). No differences were observed between groups for motion (p = 0.443). While EC was more related to ADHD psychopathology, VMHC was consistently and negatively correlated with age across all networks.

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“…Given that the extent and strength of connectivity of primary cortical semantic hubs with secondary cortical association areas depends on the demands of the task to be performed ( Binder et al, 2009 ; Bonner et al, 2013 ; Reilly et al, 2016 ), it seems likely that tasks that require greater semantic control (e.g., generative semantic production) would elicit even stronger connectivity with areas in the frontal cortex, in particular the IFG. This conceptualization regarding the role of the IFG is with models of semantic processing that posit multiple demand systems, including a semantic control network ( Noonan et al, 2013 ; Hoffman et al, 2015 ; Mineroff et al, 2018 ; Cotosck et al, 2021 ; Gao et al, 2021 ; Hodgson et al, 2021 ; Smith et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity of brain networks during semantic processing in older adults

Garcia

Cohen²,

Porges³

et al. 2022

Front. Aging Neurosci.

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The neural systems underlying semantic processing have been characterized with functional neuroimaging in young adults. Whether the integrity of these systems degrade with advanced age remains unresolved. The current study examined functional connectivity during abstract and concrete word processing. Thirty-eight adults, aged 55–91, engaged in semantic association decision tasks during a mixed event-related block functional magnetic resonance imaging (fMRI) paradigm. During the semantic trials, the task required participants to make a judgment as to whether pairs were semantically associated. During the rhyme trials, the task required participants to determine if non-word pairs rhymed. Seeds were placed in putative semantic hubs of the left anterior middle temporal gyrus (aMTG) and the angular gyrus (AG), and also in the left inferior frontal gyrus (IFG), an area considered important for semantic control. Greater connectivity between aMTG, AG, and IFG and multiple cortical areas occurred during semantic processing. Connectivity from the three seeds differed during semantic processing: the left AG and aMTG were strongly connected with frontal, parietal, and occipital areas bilaterally, whereas the IFG was most strongly connected with other frontal cortical areas and the AG in the ipsilateral left hemisphere. Notably, the strength and extent of connectivity differed for abstract and concrete semantic processing; connectivity from the left aMTG and AG to bilateral cortical areas was greater during abstract processing, whereas IFG connectivity with left cortical areas was greater during concrete processing. With advanced age, greater connectivity occurred only between the left AG and supramarginal gyrus during the processing of concrete word-pairs, but not abstract word-pairs. Among older adults, robust functional connectivity of the aMTG, AG, and IFG to widely distributed bilateral cortical areas occurs during abstract and concrete semantic processing in a manner consistent with reports from past studies of young adults. There was not a significant degradation of functional connectivity during semantic processing between the ages of 55 and 85 years. As the study focused on semantic functioning in older adults, a comparison group of young adults was not included, limiting generalizability. Future longitudinal neuroimaging studies that compare functional connectivity of young and older adults under different semantic demands will be valuable.

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Engagement of Language and Domain General Networks during Word Monitoring in a Native and Unknown Language

Cited by 8 publications

References 52 publications

Auditory dyadic interactions through the ‘eye’ of the social brain: How visual is the posterior STS interaction region?

Auditory dyadic interactions through the ‘eye’ of the social brain: How visual is the posterior STS interaction region?

Centrality and interhemispheric coordination are related to different clinical/behavioral factors in attention deficit/hyperactivity disorder: a resting-state fMRI study

Functional connectivity of brain networks during semantic processing in older adults

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