Abstract:Human adenoviruses (HAdVs) are widespread pathogens that generally cause mild infections in immunocompetent individuals, but severe or even fatal diseases in immunocompromised patients. In order to counteract the host immune defenses HAdVs encode various immunomodulatory proteins in the early transcription unit 3 (E3). The E3/49K protein is a highly glycosylated type I transmembrane protein uniquely expressed by species D adenoviruses. Its N-terminal ectodomain sec49K is released by metalloprotease-mediated sh… Show more
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