Enflurane Depresses Myocardial Function, Perfusion, and Metabolism in the Dog

Merin, Robert G.; Kumazawa, Teruo; Luka, Norman L.

doi:10.1097/00000542-197611000-00006

Cited by 88 publications

(24 citation statements)

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“…The rise in this index represents a decrease in relative oxygen supply to myocardium and the fall indicates an increase in the latter. R values for basal anesthesia, original NLA, modified NLA, morphine anesthesia and halothane anesthesia were not significantly different from each other, and they were similar to those for conscious dogs reported by Spencer et al (1950) or Merin et al (1976b). Accordingly it may be thought that these anesthesia do not disturb the mode of oxygen supply to the heart.…”

Section: Discussionsupporting

confidence: 60%

“…Previously we reported that the fall in R value associated with ether anesthesia is caused by the greater increase in coronary blood flow than in myocardial oxygen consumption, and that the fall in R value with methoxyflurane anesthesia is caused by more marked decrease in myocardial oxygen consumption than in coronary blood flow (Yusa et al 1969(Yusa et al , 1977. The fall in R value with en.flurane anesthesia may be caused by greater decrease in myocardial oxygen consumption as methoxyflurane anesthesia, because the reduction in myocardial oxygen consumption with enflurane anesthesia has been shown by Merin et al (1976b).…”

Section: Discussionmentioning

confidence: 99%

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Myocardial oxygen extraction rate under general anesthesia.

Yusa

Obara

1981

Tohoku J. Exp. Med.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Myocardial oxygen extraction rate under general anesthesia.

Yusa

Obara

1981

Tohoku J. Exp. Med.

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“…Using enflurane as the anesthetic agent, we endeavored to reproduce a situation comparable to clinical circumstances. However, we failed to avoid perturbation of the hemodynamic parameters, probably due to the fact that the dog is a little more susceptible to the cardiodepressant effect of enflurane than the human (as reported by Merin et al [17], the depressant effect of enflurane is similar to that of halothane in the dog heart), and we had to use invasive procedures to measure the regional blood flow. Thus we must be cautious in extrapolating the data obtained in the present study to clinical situations.…”

Section: Discussionmentioning

confidence: 99%

Effects of sodium nitroprusside (MR7S1) and nitroglycerin on the systemic, renal, cerebral, and coronary circulation of dogs anesthetized with enflurane

Hamaguchi

Ishibashi

Katsumata

et al. 1992

Cardiovasc Drug Ther

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In beagle dogs anesthetized with enflurane-nitrous oxide, effects of sodium nitroprusside (SNP; MR7S1) and nitroglycerin (NTG) on hemodynamics and main organ circulation were studied to evaluate their effectiveness and safety as hypotensive agents during anesthesia. SNP (MR7S1) infusion (1-10 micrograms/kg/min) decreased arterial blood pressure in a dose-dependent manner. The hypotension was stable during the infusion. After discontinuation of infusion, the blood pressure rapidly returned to the initial level. The hypotension was associated with decreases in cardiac output and total peripheral resistance. NTG infusion (3-10 micrograms/kg/min) decreased arterial blood pressure, too, but the hypotension was less marked and not dose dependent, and the recovery was slower. Neither drug changed the heart rate. Infusion of SNP (MR7S1) and NTG did not change the hypotension induced by the injection of adenosine, SNP, and NTG. Furthermore, cerebral blood flow, cerebral oxygen consumption, and renal blood flow were unchanged during the hypotension produced by either drug. Coronary blood flow was decreased, but this was due to decreases in cardiac oxygen consumption. In conclusion, SNP (MR7S1) is superior to NTG as a hypotensive agent during anesthesia in efficacy, clear dose dependency, and rapid recovery. The hypotension induced by NTG as well as SNP (MR7S1) seems to have no undesirable effects on the circulation of important organs.

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“…Although nine had signi-CAN ANAESTH SOC ] 1984 ! 31:6 I pp604-10 ficant areas of hypokinesis, normal myocardial function was present at cardiac catheterization: mean ejection fraction = 0.62 (50-78), LVEDP = 12 mmHg (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and CI = 2.77 l.min -I.m -2 (I .9-3.5).…”

Section: Study Populationmentioning

confidence: 99%

Myocardial metabolism and haemodynamic responses with enflurane anaesthesia for coronary artery surgery

et al. 1984

Can Anaesth Soc J

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The study was supported by the Nova Scotia Heart Foundation and Ohio Medical Anesthetics.Maintenance of myocardial oxygen balance during anaesthesia is essential, particularly for patients with coronary artery disease, to avoid major ischaemic episodes or frank infarction. Increased oxygen consumption due to a hyperdynamic circulation must be avoided. Moderate depression of myocardial contractility by potent anaesthetic drugs is desirable but must be controllable. The adequacy of myocardial oxygenation can now be assessed in the operating room, by measuring coronary sinus blood flow, myocardial oxygen consumption and lactate extraction. Myocardial oxygenation can be maintained in coronary patients with halothaneoxygen but not so with 1 mg.kg -l of morphine, and oxygen. ~ Delaney et al. 2 reported, in patients having coronary vein grafts (CABG), myocardial function and haemodynamic effects of enflurane, but correlation of haemodynamics with CBF, MVO2 and MLE has not been documented. We present the haemodynamic and myocardial metabolic effects of enflurane-oxygen anaesthesia from pre-induction, through anaesthesia and operation for CABG and for 24 hours afterward. Methods Study populationTen male patients gave their informed consent. Mean age was 53.7 years (range 34-62), mean weight 79.2 Kg (68-91); eight had known previous infarction. Their disability by NYHA Class was: 11 -one patient, III -seven and IV -two; all patients were normotensive. Nine were kept on effective beta blockade (average: propranolol dose 40rag q.i.d.) until operation. Although nine had signi-CAN ANAESTH SOC ] 1984 ! 31:6 I pp604-10

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Enflurane Depresses Myocardial Function, Perfusion, and Metabolism in the Dog

Cited by 88 publications

References 0 publications

Myocardial oxygen extraction rate under general anesthesia.

Myocardial oxygen extraction rate under general anesthesia.

Effects of sodium nitroprusside (MR7S1) and nitroglycerin on the systemic, renal, cerebral, and coronary circulation of dogs anesthetized with enflurane

Myocardial metabolism and haemodynamic responses with enflurane anaesthesia for coronary artery surgery

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