Enfermedad meningocócica neonatal

Fuentes, A.; Fuhrmann, C.; Santis, De

doi:10.1016/j.anpedi.2011.04.010

Cited by 3 publications

(1 citation statement)

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“…Все это многообразие терминов отражало скорость развития и тяжесть заболевания в двух его основных современных инвазивных формах: менингит и менингококцемия. У новорожденных от начала лихорадки до смерти при тяжелой менингококцемии часто проходило всего около 12 ч -с осложнениями молниеносной формой сепсиса, тяжелым септическим шоком, ацидозом, ДВС-синдромом и СПОН [18,[73][74][75].…”

Section: варианты клиники неонатальной менингококковой инфекцииunclassified

Generalized Meningococcal Disease in the Newborn: Clinical Case and Literature Review

Izvekova

2023

Pediatr. farmakol.

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Neisseria meningitidis is one of the main etiological factors of meningitis and sepsis in children and adults, however, it is rarely diagnosed in the neonatal period. Clinical definition of neonatal meningococcal disease is complicated, the disease outcome is commonly lethal, and therefore its timely diagnosis and adequate therapy are crucial. This article describes clinical case of the newborn with meningococcal sepsis hospitalized on the 5th day after birth and provides the literature review of the data from the late 19th century until the present.

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Section: варианты клиники неонатальной менингококковой инфекцииunclassified

Generalized Meningococcal Disease in the Newborn: Clinical Case and Literature Review

Izvekova

2023

Pediatr. farmakol.

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Neonatal Infection with Neisseria meningitidis: Analysis of a 97-Year Period Plus Case Study

et al. 2014

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Neisseria meningitidis is one of the major causes of meningitis in children and adolescents, but it is rarely found during the neonatal period. Here, we describe a neonate with meningococcal sepsis who was admitted to the hospital on postnatal day 10, and we discuss the clinical features of neonatal infection with N. meningitidis in relation to the literature (analysis of a 97-year period). CASE REPORTO ur case, a 10-day-old male patient, was born by normal spontaneous delivery at term with a weight of 3,380 g. During pregnancy, his mother was regularly followed up. The natal history was unremarkable. He was breastfed and discharged without any problems on postnatal day 2. The neonate was admitted to the neonatal intensive care unit due to fever and difficulty breathing. An initial physical examination of the patient revealed cutis marmorata. He was hypotonic in general and exhibited poor sucking. The results of cardiovascular and respiratory examinations were normal. The patient did not exhibit organomegaly or eruptions. The capillary filling time was 2 s. The patient's initial vital findings were as follows: axillary temperature, 38.8°C; heart rate, 190/min; respiratory rate, 55/min; and arterial blood pressure, 100/60 mm Hg. The admittance weight of the neonate was 3,530 Ϯ 150 g. The results of a complete blood count and serum biochemical analysis did not reveal any abnormalities. The patient's C-reactive protein level was normal (0.2 mg/dl).A urinalysis and chest X-ray were normal. A peripheral blood smear revealed that the immature/total neutrophil ratio was 0.3. An analysis of arterial blood gases revealed both respiratory and metabolic acidosis.Blood and urine culture samples were obtained. The patient was diagnosed with sepsis and respiratory insufficiency based on the clinical and laboratory findings. He was intubated and given respiratory support with mechanical ventilation in SIMV (simultaneous intermittent mandatory ventilation) mode. Ampicillin (100 mg/kg of body weight/day) and cefotaxime (100 mg/kg/day) were administered. Intravenous fluid was given at an infusion rate of 150 ml/kg/day. Cranial, abdominal, and urinary ultrasound investigations done during clinical follow-up were evaluated as normal.To rule out meningitis, a lumbar puncture was done; the cerebrospinal fluid (CSF) biochemistry did not reveal any abnormalities.During the second hour of hospitalization in the intensive care unit, the patient's capillary filling time was found to be increased (5 s), and hypotension and bradycardia developed; thus, he was given a 10-ml/kg bolus of physiological serum twice. Because the patient's hypotension persisted, dopamine (10 g/kg/min) and dobutamine (10 g/kg/min) were given. However, during the fifth hour of admittance, a generalized purpuric eruption (Fig. 1) that enlarged and began to coalesce developed. Laboratory testing revealed leukopenia and thrombocytopenia, prolonged coagulation, and a rise in the C-reactive protein level (3.5 mg/dl). Vitamin K (1 mg) and fresh frozen plasma (15 ml/kg) we...

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Neisseria Meningitidis Causing Multiple Cerebral Abscesses in Early Neonatal Period: Case Report and Review of Literature

Basani¹

2017

JCDR

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Enfermedad meningocócica neonatal

Cited by 3 publications

References 8 publications

Generalized Meningococcal Disease in the Newborn: Clinical Case and Literature Review

Generalized Meningococcal Disease in the Newborn: Clinical Case and Literature Review

Neonatal Infection with Neisseria meningitidis: Analysis of a 97-Year Period Plus Case Study

Neisseria Meningitidis Causing Multiple Cerebral Abscesses in Early Neonatal Period: Case Report and Review of Literature

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