Enfermedad funcional tiroidea en la población de edad avanzada

Palacios, María José; Vernet, Marine; López, Sara; Colomés, M. Faro; Blanc, Marta Rojas; Gabriël, Laurence

doi:10.1016/s0212-6567(04)78907-6

Cited by 15 publications

(6 citation statements)

References 16 publications

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“…Díez et al [26] described a prevalence of subclinical hypothyroidism around 1.02% in healthy ambulatory subjects aged from 60 to 84 years in an urban community in Madrid (Spain) and a prevalence of subclinical hyperthyroidism of 6.12%. In another study, conducted in Terrassa (Catalonia), also in older healthy ambulatory subjects, the prevalence of total hypothyroidism (overt, subclinical, and previously diagnosed) was 10.9% and that of thyroid dysfunction in general 13% [27]. These data differ from our general results, probably due to the different ages of the subjects studied and other environmental factors.…”

Section: Discussioncontrasting

confidence: 95%

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Undiagnosed thyroid dysfunction, thyroid antibodies, and iodine excretion in a Mediterranean population

Lucas

Julián

Cantón

et al. 2010

Endocr

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The prevalence of thyroid dysfunction varies in different populations. The aim of this cross-sectional study was to analyze the prevalence of undiagnosed thyroid dysfunction and thyroid antibodies and their relationship with urine iodine excretion in a representative sample of 1,124 (55.5% women; mean age: 44.8 ± 15.2 years) non-hospitalized Mediterranean adults, in Catalonia (Spain). Free thyroxine, thyroid-stimulating hormone, thyroperoxidase and thyroglobulin antibodies, and urine iodine were measured. Undiagnosed thyroid dysfunction was 5.3% (hypothyroidism 3.8%; 56.66% of these subjects were women). The total (diagnosed + undiagnosed) thyroid dysfunction was 8.9% (71.15% women). Thyroperoxidase antibodies were positive in 2.4% of men and 9.4% of women and thyroglobulin antibodies, in 1.3% of men and 3.8% of women. No differences were observed in urine iodine between groups with thyroid dysfunction and euthyroidism, or between subjects with positive or negative antibodies. In subjects over 60, undiagnosed thyroid dysfunction was 9.8% (hypothyroidism 6.9%, hyperthyroidism 3.3%; 36.36% women) and total thyroid dysfunction 13.61% (53.12% women). Women and men over 60 had similar thyroid dysfunction prevalence. Thus, aggressive case-finding should be recommended in both, over 60.

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Section: Discussioncontrasting

confidence: 95%

“…If subjects over 60 with diagnosed thyroid disease are also considered, the total prevalence (diagnosed ? undiagnosed) of thyroid dysfunction in this group was 13.61%, similar to that reported by Sender Palacios et al [27]. Women constituted 53.12% of these subjects and 46.87% were men.…”

Section: Discussionsupporting

confidence: 91%

Undiagnosed thyroid dysfunction, thyroid antibodies, and iodine excretion in a Mediterranean population

Lucas

Julián

Cantón

et al. 2010

Endocr

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“…The SCH prevalence of 9.7% is in good agreement with the 9.2-9.5% reported so far (1, 6). As previously published (10, 11), the mean TSH level increased with aging to reach a prevalence of a diagnosed SCH prevalence of 11.7% (8.4% for <60y group), in agreement with the 10.4-14.5% found in European citizens ≥60y (12, 36). Unfortunately, given the context of the study, which was conducted in current care, we were not able to perform follow up measurements of thyroid function markers or to follow evolution of the diagnosed SCH prevalence in our cohort.…”

Section: Discussionsupporting

confidence: 89%

Subclinical Hypothyroidism: is it Really Subclinical with Aging?

Gourmelon¹,

Donadio-Andréi²,

Chikh³

et al. 2019

Aging and disease

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No recent study has focused on clinical features of subclinical hypothyroidism (SCH), especially in older patients. TSH measurement has remarkably evolved these last 20 years and thus reconsideration is needed. In our prospective multicenter study (2012-2014) including 807 subjects aged <60 years (<60y) and 531 subjects ≥60 years (≥60y), we have monitored 11 hypothyroidism-related clinical signs (hCS) together with TSH, FT4, FT3 and anti-thyroperoxidase antibodies values. hCS expression has been compared in patients with SCH vs euthyroidism in each age group. The number of hCS above 60y of age were found to be more elevated in the euthyroid population (1.9 vs 1.6, p<0.01) than in the SCH population (2.3 vs 2.6, p=0.41) while increase in hCS is limited to SCH subjects in the <60y group (p<0.01). The percentage of subjects with at least 3 signs increased with SCH in the <60y group (42.6% vs 25.0%, p<0.01) but not ≥60y (34.4% vs 33.9%, p=0.96). In older individuals, only three hCS could be related to both SCH and a decreased T3/T4-ratio (0.26 vs 0.27, p<0.01), suggesting either a reduced activity of TSH, or an adaptive response with aging. While hCS are clearly associated with SCH in patients <60y, they are not so informative in older subjects. TSH measurements carried out on the basis of hCS need to be interpreted with caution in aged patients. A reassessment of the TSH reference range in older patients is clearly needed and should be associated to more appropriate monitoring of thyroid dysfunction

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“…The prevalence of thyroid dysfunction found in the present study was similar to that reported in other studies performed in aged population in our country, which ranged from 4 to 13%. [14][15][16][17][18][19][20] Although it has been generally admitted that the prevalence of thyroid dysfunction in the elderly is higher in hospitalized and institutionalized patients than in general population, 21-24 these findings have not been confirmed in elderly population in our area. 18 It is remarkable that prevalence of thyroid dysfunction found in Spanish populations has been lower than that reported in American population.…”

Section: Discussionmentioning

confidence: 98%