Enfermedad del injerto contra el huésped crónica liquenoide con patrón blaschkoide

Psoriasiform graft‐versus‐host disease distributed along Blaschko's lines

“…In addition to its rare morphologic appearance, this case presents a unique pattern of distribution along lines of Blaschko, which is a rare form of linear cGVHD and of which there are also few reports in the literature. [21][22][23][24][25] The lines of Blaschko represent the migration of embryonic cells in the skin, 12 and are otherwise unseen unless there are variations of DNA sequencing or gene expression in these cell lines. Such variations may then manifest in the typical whorled pattern associated with the path of the cells' migration.…”

“…The prevailing theory accounting for cGVHD occurring in a Blaschkoid fashion proposes that the donor lymphocytes expose a somatic mosaicism in the host cells; this mosaicism had previously been tolerated by the host's own lymphocytes and was therefore masked. 21,22 The donor cells target the host's genetically varied cells, which have migrated in a particular pattern over time, thus resulting in a swirling presentation of cGVHD. Differential diagnosis of such inflammatory lichenoid lesions along Blaschko's lines should include blaschkitis, a self-limited condition of pruritic papules and vesicles which typically resolve in weeks to months which can be differentiated from psoriasiform GVHD by its morphology, relapsing course and non-specific histological findings of spongiotic dermatitis.…”

Factores de riesgo y reacciones adversas postransfusionales en pacientes hospitalizados en una institución privada de la ciudad de Guayaquil en el año 2022

“…c) Enfermedad Injerto contra el Huésped La enfermedad de injerto-huésped (EICH) es un síndrome clínico que se produce cuando las células inmunocompetentes de un donante cuando atacan varios tejidos del huésped, siendo la piel, el tracto gastrointestinal y el hígado los principales órganos diana. La enfermedad cutánea crónica por EICH suele aparecer 100 días después del trasplante (Kennedya, Hilaria, Ferrer, & Garcia., 2014).…”