Enfermedad del hígado graso no alcohólico, asociación con la enfermedad cardiovascular y tratamiento (II). Tratamiento de la enfermedad del hígado graso no alcohólico

Brea, Ángel; Pintó, Xavier; Ascaso, Juan F.; Blasco, Mariano; Díaz, Ángel; González-Santos, Pedro; Hernández‐Mijares, Antonio; Mantilla, Teresa; Millán, Jesús; Pedro‐Botet, Juan

doi:10.1016/j.arteri.2016.06.002

Cited by 7 publications

(5 citation statements)

References 203 publications

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“…Cellular and intracellular membranes have been recognized to be the targets for the damaging action of this xenobiotic, and lipid peroxidation has been considered as an important mechanism of its hepatotoxicity. Oxidative damage to cellular macromolecules may result in serious injury of hepatocytes, leading to morphological and functional changes in the liver, which may have detrimental consequences for the organism [4,5,11,25]. Therefore, it is very important to find an effective way to protect against liver injury, especially by chemical substances to which humans are exposed within a lifetime and which, like Cd, progressively accumulate in this organ [4,17], and also important to explain the mechanisms of this protection.…”

Section: Introductionmentioning

confidence: 99%

Extract from Aronia melanocarpa L. Berries Protects Against Cadmium-induced Lipid Peroxidation and Oxidative Damage to Proteins and DNA in the Liver: A Study using a Rat Model of Environmental Human Exposure to this Xenobiotic

et al. 2019

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It was investigated, using a female rat model of low and moderate exposure of human to cadmium (Cd, 1 and 5 mg Cd/kg diet for 3–24 months), whether a polyphenol-rich 0.1% aqueous extract from Aronia melanocarpa L. berries (AE) may prevent Cd-induced lipid peroxidation and oxidative modifications of proteins and deoxyribonucleic acid (DNA) in the liver. For this purpose, markers of lipid peroxidation (lipid peroxides and 8-isoprostane) and oxidative injury of proteins (protein carbonyl groups and 3-nitrotyrosine) and DNA (8-hydroxy-2′-deoxyguanosine) were measured in this organ. The expression of metallothionein 1 (MT1) and metallothionein 2 (MT2) genes was estimated for a better explanation of the possible mechanisms of protective action of AE against Cd hepatotoxicity. The low and moderate treatment with Cd induced lipid peroxidation and oxidatively modified proteins and DNA, as well as enhanced the expression of MT1 and MT2 in the liver, whereas the co-administration of AE completely prevented almost all of these effects. The results allow us to conclude that the consumption of aronia products under exposure to Cd may offer protection against oxidative injury of the main cellular macromolecules in the liver, including especially lipid peroxidation, and in this way prevent damage to this organ.

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Section: Introductionmentioning

confidence: 99%

Extract from Aronia melanocarpa L. Berries Protects Against Cadmium-induced Lipid Peroxidation and Oxidative Damage to Proteins and DNA in the Liver: A Study using a Rat Model of Environmental Human Exposure to this Xenobiotic

et al. 2019

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“…This organ, due to its role in the biotransformation (detoxification or metabolic activation), storage of numerous xenobiotics that enter the body from various sources (mainly contaminants of food and drinking water, medicines, and ethyl alcohol), and some endogenous substances, is especially prone to damage by various noxious compounds and poisonous products of their biotransformation, including free radicals (FR) [1]. Because the liver plays a key role in the proper functioning of the organism, its dysfunction has numerous negative outcomes [20,21,22]. Thus, it is very important to find effective agents allowing to improve the function of this organ and protect it from damage by various xenobiotics, including Cd which is accumulated in the hepatic tissue during a lifetime.…”

Section: Introductionmentioning

confidence: 99%

Extract from Aronia melanocarpa L. Berries Prevents Cadmium-Induced Oxidative Stress in the Liver: A Study in A Rat Model of Low-Level and Moderate Lifetime Human Exposure to this Toxic Metal

et al. 2018

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The study investigated, in a rat model of low-level and moderate environmental exposure to cadmium (Cd; 1 or 5 mg Cd/kg diet, respectively, for 3 to 24 months), whether the co-administration of 0.1% extract from Aronia melanocarpa L. berries (AE) may protect against oxidative stress in the liver and in this way mediate this organ status. The intoxication with Cd, dose- and duration-dependently, weakened the enzymatic antioxidative barrier, decreased the concentrations of reduced glutathione and total thiol groups, and increased the concentrations of oxidized glutathione, hydrogen peroxide, xanthine oxidase, and myeloperoxidase in this organ. These resulted in a decrease in the total antioxidative status, increase in the total oxidative status and development of oxidative stress (increased oxidative stress index and malondialdehyde concentration) and histopathological changes in the liver. The administration of AE at both levels of Cd treatment significantly improved the enzymatic and nonenzymatic antioxidative barrier, decreased pro-oxidant concentration, and protected from the development of oxidative stress in the liver and changes in its morphology, as well as normalized the serum activities of liver enzymes markers. In conclusion, consumption of aronia products may prevent Cd-induced destroying the oxidative/antioxidative balance and development of oxidative stress in the liver protecting against this organ damage.

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“…As the liver is one of the target organs for Cd and disturbances in the proper functioning of this organ have serious consequences for health (Brea et al, 2017;Chang et al, 2012;Targher et al, 2008), in the present review our attention has been focused on polyphenol-rich food products as a possible effective strategy in the protection from Cd hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of divalent metals, including toxic metals (Borowska, Brzóska, & Tomczyk, 2018;Dai, Dong, & Ma, 2012;Horniblow, Henesy, Iqbal, & Tselepis, 2017;Jayanta & Shukla, 2014;Primikyri et al, 2015;Ravichandran, Rajendran, & Devapiriam, 2014), and strong antioxidative potential of these compounds (Brzóska, Borowska, & Tomczyk, 2016, as well as their abundance in dietary products (Brzóska, Borowska, & Tomczyk, 2016;Brzóska, Rogalska, et al, 2016;Quideau, Deffieux, Douat-Casassus, & Pouységu, 2011), it seems to be of high importance to consider the possibility of using polyphenols as potential FIGURE 1 Function of the liver in the organism [Colour figure can be viewed at wileyonlinelibrary.com] preventive and therapeutic agents against Cd hepatotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

Mężyńska

Brzóska

2018

J of Applied Toxicology

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Recently, the growing attention of the scientific community has been focused on the threat to health created by environmental pollutants, including toxic metals such as cadmium (Cd), and on the need of finding effective ways to prevent and treat the unfavorable health effects of exposure to them. Particularly promising for Cd, and thus arousing the greatest interest, is the possibility of using various ingredients present in plants, including mainly polyphenolic compounds. As the liver is one of the target organs for this toxic metal and disturbances in the proper functioning of this organ have serious consequences for health, the aim of the present review was to discuss the possibility of using polyphenol-rich food products (e.g., chokeberry, black and green tea, blueberry, olive oil, rosemary and ginger) as the strategy in protection from this xenobiotic hepatotoxicity and treatment of this heavy metal-induced liver damage. Owing to the ability of polyphenols to bind ions of Cd and the strong antioxidative potential of these compounds, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols as potential preventive and therapeutic agents against Cd hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols comes from studies in animals, the fact that some of them are derived from experimental models that reflect human exposure to this metal allows us to assume that some polyphenol-rich food products may be promising protective agents against Cd hepatotoxicity in humans.

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Enfermedad del hígado graso no alcohólico, asociación con la enfermedad cardiovascular y tratamiento (II). Tratamiento de la enfermedad del hígado graso no alcohólico

Cited by 7 publications

References 203 publications

Extract from Aronia melanocarpa L. Berries Protects Against Cadmium-induced Lipid Peroxidation and Oxidative Damage to Proteins and DNA in the Liver: A Study using a Rat Model of Environmental Human Exposure to this Xenobiotic

Extract from Aronia melanocarpa L. Berries Protects Against Cadmium-induced Lipid Peroxidation and Oxidative Damage to Proteins and DNA in the Liver: A Study using a Rat Model of Environmental Human Exposure to this Xenobiotic

Extract from Aronia melanocarpa L. Berries Prevents Cadmium-Induced Oxidative Stress in the Liver: A Study in A Rat Model of Low-Level and Moderate Lifetime Human Exposure to this Toxic Metal

Review of polyphenol‐rich products as potential protective and therapeutic factors against cadmium hepatotoxicity

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