Enfermedad de Carrión grave complicada con leptospirosis aguda: reporte de un caso

Huerta, Anderson; Salas, Marcia; Yarinsueca, Jorge; Maguiña, Ciro

doi:10.17843/rpmesp.2014.312.63

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…In the acute stage (the so-called Oroya fever) severe haemolytic anaemia is present, resulting in 40–85% of deaths in untreated people and decreases to around 10% if correctly treated 1 2 3 . In this stage the presence of concomitant infections such as bloodstream Salmonella infections, among others 1 4 5 6 , are frequent due to the temporal immunosuppression induced by B. bacilliformis 7 .…”

mentioning

confidence: 99%

Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants

Gomes

Martínez-Puchol

Ruiz-Roldán

et al. 2016

Sci Rep

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The objective was to develop and characterise in vitro Bartonella bacilliformis antibiotic resistant mutants. Three B. bacilliformis strains were plated 35 or 40 times with azithromycin, chloramphenicol, ciprofloxacin or rifampicin discs. Resistance-stability was assessed performing 5 serial passages without antibiotic pressure. MICs were determined with/without Phe-Arg-β-Napthylamide and artesunate. Target alterations were screened in the 23S rRNA, rplD, rplV, gyrA, gyrB, parC, parE and rpoB genes. Chloramphenicol and ciprofloxacin resistance were the most difficult and easiest (>37.3 and 10.6 passages) to be selected, respectively. All mutants but one selected with chloramphenicol achieved high resistance levels. All rifampicin, one azithromycin and one ciprofloxacin mutants did not totally revert when cultured without antibiotic pressure. Azithromycin resistance was related to L4 substitutions Gln-66 → Lys or Gly-70 → Arg; L4 deletion Δ62–65 (Lys-Met-Tyr-Lys) or L22 insertion 83::Val-Ser-Glu-Ala-His-Val-Gly-Lys-Ser; in two chloramphenicol-resistant mutants the 23S rRNA mutation G2372A was detected. GyrA Ala-91 → Val and Asp-95 → Gly and GyrB Glu474 → Lys were detected in ciprofloxacin-resistant mutants. RpoB substitutions Gln-527 → Arg, His-540 → Tyr and Ser-545 → Phe plus Ser-588 → Tyr were detected in rifampicin-resistant mutants. In 5 mutants the effect of efflux pumps on resistance was observed. Antibiotic resistance was mainly related to target mutations and overexpression of efflux pumps, which might underlie microbiological failures during treatments.

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confidence: 99%

Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants

Gomes

Martínez-Puchol

Ruiz-Roldán

et al. 2016

Sci Rep

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“…Debido a la virulencia del serovar en mención que se vincula a cuadros graves causando daño severo a nivel hepático y renal, la forma ictérica de la enfermedad reportada en el paciente de nuestro estudio es una consecuencia de graves trastornos hepáticos, renales o pulmonares causadas por leptospiras situadas en estos órganos (10,18,19).…”

Section: Discussionunclassified

Cuadro ictérico hemorrágico grave causado por Leptospira interrogans serovar Icterohaemorrhagiae

Rojas‐Jaimes

Parrales-Donayre²,

Anquise³

2016

CES Med

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“…The mortality rate in the acute phase is 40 to 85% in untreated patients; however, in reference centers (where severe cases are treated) with appropriate and timely treatment, this rate can be reduced to values of around 10% (6,15,78,139,141,142). Complications or secondary opportunistic infections can dramatically worsen the clinical outcome, and unfortunately, they are quite common (29,33,78,(142)(143)(144). There are several reports on noninfectious hematological, cardiovascular, and neurological complications (29,33,140).…”

Section: Oroya Fevermentioning

confidence: 99%

Carrion's Disease: the Sound of Silence

2018

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Carrion's disease (CD) is a neglected biphasic vector-borne illness related to . It is found in the Andean valleys and is transmitted mainly by members of the genus but also by blood transfusions and from mother to child. The acute phase, Oroya fever, presents severe anemia and fever. The lethality is high in the absence of adequate treatment, despite the organism being susceptible to most antibiotics. Partial immunity is developed after infection by , resulting in high numbers of asymptomatic carriers. Following infection there is the chronic phase, Peruvian warts, involving abnormal proliferation of the endothelial cells. Despite potentially being eradicable, CD has been expanded due to human migration and geographical expansion of the vector. Moreover, studies have demonstrated the risk of the development of antimicrobial resistance. These findings, together with the description of new species producing CD-like infections, the presence of undescribed potential vectors in new areas, the lack of adequate diagnostic tools and knowledge of the immunology and bacterial pathogenesis of CD, and poor international visibility, have led to the risk of increasing the potential expansion of resistant strains which will challenge current treatment schemes as well as the possible appearance of CD in areas where it is not endemic.

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Enfermedad de Carrión grave complicada con leptospirosis aguda: reporte de un caso

Cited by 5 publications

References 7 publications

Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants

Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants

Cuadro ictérico hemorrágico grave causado por Leptospira interrogans serovar Icterohaemorrhagiae

Carrion's Disease: the Sound of Silence

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