“…Cav-1, the major structural protein of caveolae, functions as scaffolding protein [21] regulating multiple physiological processes including caveola biogenesis, vesicular transport, cholesterol homeostasis, and signal transduction [22]. Recently, Cav-1 has been demonstrated to be closely involved in tumorigenesis and development, affecting the proliferation [23, 24], survival [25, 26], apoptosis [27, 28], migration [29, 30], invasion [24, 31], metastasis [32, 33], autophagy [34, 35], transformation [36], anoikis [37, 38], and chemotherapy resistance [39, 40] processes of cancer cells. Cav-1 is generally regarded as a tumor suppressor, and studies have implicated loss of Cav-1 in the pathogenesis and progression of multiple human cancers [41–44].…”