Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements

Johansson, Hans-Erik; Edholm, David; Kullberg, Joel; Rosqvist, Fredrik; Rudling, Mats; Straniero, Sara; Karlsson, F. Anders; Åhlström, Håkan; Sundbom, Magnus; Risérus, Ulf

doi:10.1038/s41387-019-0100-2

Cited by 13 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it could be inferred that on the premise of energy restriction, no matter IER or CER strategy is adopted, daily fat intake should be first reduced to ensure to create sufficient energy deficiency. This prediction is consistent with the nutritional recommendations of previous studies [ 78 , 79 , 80 ].…”

Section: Discussionsupporting

confidence: 92%

The Comparison of the Effects between Continuous and Intermittent Energy Restriction in Short-Term Bodyweight Loss for Sedentary Population: A Randomized, Double-Blind, Controlled Trial

Zou

et al. 2021

IJERPH

View full text Add to dashboard Cite

Objective: To compare the effects of continuous energy restriction (CER) and intermittent energy restriction (IER) in bodyweight loss plan in sedentary individuals with normal bodyweight and explore the influence factors of effect and individual retention. Methods: 26 participants were recruited in this randomized controlled and double-blinded trial and allocated to CER and IER groups. Bodyweight (BW), body mass index (BMI), and resting metabolic rate (RMR) would be collected before and after a 4-week (28 days) plan which included energy restriction (CER or IER) and moderate-intensity exercise. Daily intake of three major nutrients (protein, carbohydrate, fat) and calories were recorded. Results: A significant decrease in BW and BMI were reported within each group. No statistically significant difference in the change of RMR in CERG. No statistically significant difference was reported in the effect between groups, neither as well the intake of total calories, three major nutrients, and individual plan retention. The influence factors of IER and CER are different. Conclusion: Both CER and IER are effective and safe energy restriction strategies in the short term. Daily energy intake and physical exercise are important to both IER and CER.

show abstract

Section: Discussionsupporting

confidence: 92%

The Comparison of the Effects between Continuous and Intermittent Energy Restriction in Short-Term Bodyweight Loss for Sedentary Population: A Randomized, Double-Blind, Controlled Trial

Zou

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Although the KD improved all metabolic abnormalities of NAFLD in just 6 d, there were also some adverse effects. The AST/ALT ratio increased by ∼34% during the diet ( Table 1), suggesting that such a rapid weight loss could induce a transient hepatocellular injury, consistent with a previous study (50). In addition, the metabolic changes induced by the 6-d KD closely resembled those seen in starvation (35).…”

Section: Discussionsupporting

confidence: 87%

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

Luukkonen

Dufour

Lyu

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

159

153

View full text Add to dashboard Cite

Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin resistance despite increasing circulating nonesterified fatty acids (NEFA), the main substrate for synthesis of intrahepatic triglycerides (IHTG). To explore the underlying mechanism, we quantified hepatic mitochondrial fluxes and their regulators in humans by using positional isotopomer NMR tracer analysis. Ten overweight/obese subjects received stable isotope infusions of: [D7]glucose, [13C4]β-hydroxybutyrate and [3-13C]lactate before and after a 6-d KD. IHTG was determined by proton magnetic resonance spectroscopy (1H-MRS). The KD diet decreased IHTG by 31% in the face of a 3% decrease in body weight and decreased hepatic insulin resistance (−58%) despite an increase in NEFA concentrations (+35%). These changes were attributed to increased net hydrolysis of IHTG and partitioning of the resulting fatty acids toward ketogenesis (+232%) due to reductions in serum insulin concentrations (−53%) and hepatic citrate synthase flux (−38%), respectively. The former was attributed to decreased hepatic insulin resistance and the latter to increased hepatic mitochondrial redox state (+167%) and decreased plasma leptin (−45%) and triiodothyronine (−21%) concentrations. These data demonstrate heretofore undescribed adaptations underlying the reversal of NAFLD by KD: That is, markedly altered hepatic mitochondrial fluxes and redox state to promote ketogenesis rather than synthesis of IHTG.

show abstract

“…In hepatic tissue, even mild CR notably suppressed proinflammatory and lipogenic gene expression of molecules such as MCP-1, SREBPs, and peroxisome proliferator-activated receptor (PPAR)-γ [61]. These evidences suggest that CR successfully regulates the symptomatic prevalence of senoinflammation that expands to pathological conditions such as chronic inflammation, insulin resistance, and low energy metabolism [17,58,62,63].…”

Section: Anti-senoinflammatory Effect Of Crmentioning

confidence: 96%

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

et al. 2020

View full text Add to dashboard Cite

Chronic inflammation, a pervasive feature of the aging process, is defined by a continuous, multifarious, low-grade inflammatory response. It is a sustained and systemic phenomenon that aggravates aging and can lead to age-related chronic diseases. In recent years, our understanding of age-related chronic inflammation has advanced through a large number of investigations on aging and calorie restriction (CR). A broader view of age-related inflammation is the concept of senoinflammation, which has an outlook beyond the traditional view, as proposed in our previous work. In this review, we discuss the effects of CR on multiple phases of proinflammatory networks and inflammatory signaling pathways to elucidate the basic mechanism underlying aging. Based on studies on senoinflammation and CR, we recognized that senescence-associated secretory phenotype (SASP), which mainly comprises cytokines and chemokines, was significantly increased during aging, whereas it was suppressed during CR. Further, we recognized that cellular metabolic pathways were also dysregulated in aging; however, CR mimetics reversed these effects. These results further support and enhance our understanding of the novel concept of senoinflammation, which is related to the metabolic changes that occur in the aging process. Furthermore, a thorough elucidation of the effect of CR on senoinflammation will reveal key insights and allow possible interventions in aging mechanisms, thus contributing to the development of new therapies focused on improving health and longevity.

show abstract

Energy restriction in obese women suggest linear reduction of hepatic fat content and time-dependent metabolic improvements

Cited by 13 publications

References 20 publications

The Comparison of the Effects between Continuous and Intermittent Energy Restriction in Short-Term Bodyweight Loss for Sedentary Population: A Randomized, Double-Blind, Controlled Trial

The Comparison of the Effects between Continuous and Intermittent Energy Restriction in Short-Term Bodyweight Loss for Sedentary Population: A Randomized, Double-Blind, Controlled Trial

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

Anti-Aging Effects of Calorie Restriction (CR) and CR Mimetics Based on the Senoinflammation Concept

Contact Info

Product

Resources

About