Energy metabolism inhibitors - a new group of antituberculous drugs

Abstract

The treatment of tuberculosis, despite the intensification of research into new drugs, remains a current problem of phthisiopulmonology due to the emergence of mycobacteria with multiple and extensive resistance, decreased patient adherence to treatment due to long duration of treatment and side effects, transformation of mycobacteria into latent metabolic forms. Elucidation of new compounds influencing metabolism and energy processes opens new perspectives to optimize the treatment of TB-MDR and TB-XDR, as well as the development of new therapeutic regimens that would shorten the duration of treatment by reducing the incidence of adverse reactions and increasing patient compliance