The potential of carbon dioxide emissions mitigation in the building sector can be achieved through energy policies, progressive goals, and support systems to attain sustainable constructions that guarantee the reduction of emissions. Net-Zero Energy Buildings (NZEB) is a concept that allows moving forward to neutralize buildings’ carbon emissions. This has been demonstrated by more industrial countries which have set goals and challenges to progressively approach an energy neutrality balance for buildings. Therefore, the target of this research is to define a framework for a new standard to reach NZEB in Chile. Firstly, an exhaustive review of the energy policies, NZEB definitions, and components of an NZEB system took place. Secondly, focus group discussions with local and international professionals from the building sector were organized to define a vision, opportunities, and potential measures with a focus on policies, to implement and develop local technologies for NZEB buildings in Chile. The study identifies the need to advance public policies to achieve an integrated policy for the implementation of energy neutral concept buildings. Finally, the paper presents a NZEB standard framework, including key performance indicators and suggested performance metrics thresholds.